Background Chronic heart failure ( CHF) is characterized by a high mortality in the elderly. Moreover, depression status is also related to poor prognosis in advancing age. Thus, we sought to determine whether depressive status predicts long- term mortality in subject with or without CHF. Methods and results Long- term mortality after 12- year follow- up in 125 elderly subjects with CHF and 1143 elderly subjects without CHF was studied. Depression was evaluated using the Geriatric Depression Scale ( GDS), and all subjects were stratified in tertiles according to GDS score ( 0- 10, 11- 20 and 21- 30). With increasing GDS score, long- term mortality at the end of follow- up increased from 43 4% to 72 0% in subjects without ( P < 0 001) and from 52 6% to 83 9% in subjects with ( P < 0 007) CHF. In multivariate analysis, GDS appeared to be predictive of long- term mortality in the absence ( Hazard ratio = 1 01; confidence interval 95% 1 00- 1 05; P = 0 04) and, even more, in the presence of CHF ( Hazard ratio = 1 08; confidence interval 95% 1 01- 1 15; P < 0 01). Conclusions Depression symptoms predict long- term mortality in elderly subjects without and, even more, with CHF. Thus, depression can be considered a strong predictor of death in CHF elderly subjects.

Testa, G., Cacciatore, F., Galizia, G., Della-Morte, D., Mazzella, F., Gargiulo, G., et al. (2011). Depressive symptoms predict mortality in elderly subjects with chronic heart failure. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 41(12), 1310-1317 [10.1111/j.1365-2362.2011.02544.x].

Depressive symptoms predict mortality in elderly subjects with chronic heart failure

Della-Morte, David;
2011-05-25

Abstract

Background Chronic heart failure ( CHF) is characterized by a high mortality in the elderly. Moreover, depression status is also related to poor prognosis in advancing age. Thus, we sought to determine whether depressive status predicts long- term mortality in subject with or without CHF. Methods and results Long- term mortality after 12- year follow- up in 125 elderly subjects with CHF and 1143 elderly subjects without CHF was studied. Depression was evaluated using the Geriatric Depression Scale ( GDS), and all subjects were stratified in tertiles according to GDS score ( 0- 10, 11- 20 and 21- 30). With increasing GDS score, long- term mortality at the end of follow- up increased from 43 4% to 72 0% in subjects without ( P < 0 001) and from 52 6% to 83 9% in subjects with ( P < 0 007) CHF. In multivariate analysis, GDS appeared to be predictive of long- term mortality in the absence ( Hazard ratio = 1 01; confidence interval 95% 1 00- 1 05; P = 0 04) and, even more, in the presence of CHF ( Hazard ratio = 1 08; confidence interval 95% 1 01- 1 15; P < 0 01). Conclusions Depression symptoms predict long- term mortality in elderly subjects without and, even more, with CHF. Thus, depression can be considered a strong predictor of death in CHF elderly subjects.
25-mag-2011
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09
English
Con Impact Factor ISI
Chronic heart failure
depression
elderly
mortality
Testa, G., Cacciatore, F., Galizia, G., Della-Morte, D., Mazzella, F., Gargiulo, G., et al. (2011). Depressive symptoms predict mortality in elderly subjects with chronic heart failure. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 41(12), 1310-1317 [10.1111/j.1365-2362.2011.02544.x].
Testa, G; Cacciatore, F; Galizia, G; Della-Morte, D; Mazzella, F; Gargiulo, G; Langellotto, A; Raucci, C; Ferrara, N; Rengo, F; Abete, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/323144
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