Background and Purpose-Few studies have examined the early effects of statins on carotid artery elasticity, a potential surrogate marker of cardiovascular risk. This study examined the short-term effects of atorvastatin 80 mg daily on carotid elasticity measured by high-resolution B-mode ultrasound.Methods-The study included 40 stroke-free and statin-naive subjects older than age 45 (mean age, 70 +/- 7 years; 55% men; 64% Caribbean-Hispanic). Outcome measures included carotid stiffness indices at 14 and 30 days after initiation of treatment. The systolic and diastolic diameters of the right common carotid artery were averaged from multiple B-mode imaging frames. Absolute and relative changes of strain [(systolic diameter-diastolic diameter)/diastolic diameter], stiffness (beta) [In (systolic/diastolic blood pressure)/strain], and distensibility (1/beta adjusted for wall thickness) from baseline were compared by the repeated measures t test and were considered significant at alpha = 0.05.Results-Baseline mean stiffness was 0.08 (95% confidence interval [CI], 0.06-0.10). It significantly decreased at day 30 to 0.05 (CI, 0.04-0.06; P<0.01). Mean baseline distensibility was 15.25 (CI, 13.18-17.32), increasing significantly at day 30 to 17.23 (CI, 14.01-20.45; P<0.05). An improvement in distensibility of >= 10% from baseline was observed in 29 (73%) subjects. Changes in stiffness and distensibility were maximal among subjects with baseline low-density lipoprotein levels <130 mg/dL.Conclusions-Short-term treatment with high-dose atorvastatin was associated with improvement in the carotid elasticity metrics. Carotid artery elasticity measured by B-mode ultrasound is a simple noninvasive measure of arterial wall function and may be a useful surrogate end point in clinical trials targeting individuals at increased risk for atherosclerosis. (Stroke. 2011; 42: 3460-3464.)

Ratchford, E.v., Gutierrez, J., Lorenzo, D., Mcclendon, M.s., Della-Morte, D., Derosa, J.t., et al. (2011). Short-term effect of atorvastatin on carotid artery elasticity: a pilot study. STROKE, 42(12), 3460-3464 [10.1161/STROKEAHA.111.625418].

Short-term effect of atorvastatin on carotid artery elasticity: a pilot study

Della-Morte, David;
2011-12-01

Abstract

Background and Purpose-Few studies have examined the early effects of statins on carotid artery elasticity, a potential surrogate marker of cardiovascular risk. This study examined the short-term effects of atorvastatin 80 mg daily on carotid elasticity measured by high-resolution B-mode ultrasound.Methods-The study included 40 stroke-free and statin-naive subjects older than age 45 (mean age, 70 +/- 7 years; 55% men; 64% Caribbean-Hispanic). Outcome measures included carotid stiffness indices at 14 and 30 days after initiation of treatment. The systolic and diastolic diameters of the right common carotid artery were averaged from multiple B-mode imaging frames. Absolute and relative changes of strain [(systolic diameter-diastolic diameter)/diastolic diameter], stiffness (beta) [In (systolic/diastolic blood pressure)/strain], and distensibility (1/beta adjusted for wall thickness) from baseline were compared by the repeated measures t test and were considered significant at alpha = 0.05.Results-Baseline mean stiffness was 0.08 (95% confidence interval [CI], 0.06-0.10). It significantly decreased at day 30 to 0.05 (CI, 0.04-0.06; P<0.01). Mean baseline distensibility was 15.25 (CI, 13.18-17.32), increasing significantly at day 30 to 17.23 (CI, 14.01-20.45; P<0.05). An improvement in distensibility of >= 10% from baseline was observed in 29 (73%) subjects. Changes in stiffness and distensibility were maximal among subjects with baseline low-density lipoprotein levels <130 mg/dL.Conclusions-Short-term treatment with high-dose atorvastatin was associated with improvement in the carotid elasticity metrics. Carotid artery elasticity measured by B-mode ultrasound is a simple noninvasive measure of arterial wall function and may be a useful surrogate end point in clinical trials targeting individuals at increased risk for atherosclerosis. (Stroke. 2011; 42: 3460-3464.)
1-dic-2011
Pubblicato
Rilevanza internazionale
Articolo
Esperti non anonimi
Settore MED/09 - MEDICINA INTERNA
English
Con Impact Factor ISI
carotid arteries
carotid ultrasound
elasticity
statins
Ratchford, E.v., Gutierrez, J., Lorenzo, D., Mcclendon, M.s., Della-Morte, D., Derosa, J.t., et al. (2011). Short-term effect of atorvastatin on carotid artery elasticity: a pilot study. STROKE, 42(12), 3460-3464 [10.1161/STROKEAHA.111.625418].
Ratchford, Ev; Gutierrez, J; Lorenzo, D; Mcclendon, Ms; Della-Morte, D; Derosa, Jt; Elkind, Msv; Sacco, Rl; Rundek, T
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/323143
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