The present invention relates to the fields of molecular biology and medicine. The invention is based on the innovative concept of "cross-kingdom functional sequence homology" between plant and mammalian microRNAs (miR- NAs), where plant miRNAs explicit a regulation mechanism into the host mammalian cell, comparable to the endogenous one. More specifically, the invention relates to identification of specific plant miRNA from Olea europea, Moringa oleifera and other Mediterranean and medicinal plants which inhibits in vitro proliferation of human acute leukemia cells, and is fit for the nutraceutical compositions comprising the miRNA

Colizzi, V., Cirillo, M., Galgani, A., DEL GALLO DI ROCCAGIOVINE, F., Kenzo, M., Minutolo, A., et al. (2016). Nutraceutical plant derived microrna elements for treatment of leukemia.

Nutraceutical plant derived microrna elements for treatment of leukemia.

Vittorio COLIZZI;Andrea GALGANI;Antonella MINUTOLO;Carla MONTESANO;Marina POTESTÀ;Ivana Matic
2016-03-09

Abstract

The present invention relates to the fields of molecular biology and medicine. The invention is based on the innovative concept of "cross-kingdom functional sequence homology" between plant and mammalian microRNAs (miR- NAs), where plant miRNAs explicit a regulation mechanism into the host mammalian cell, comparable to the endogenous one. More specifically, the invention relates to identification of specific plant miRNA from Olea europea, Moringa oleifera and other Mediterranean and medicinal plants which inhibits in vitro proliferation of human acute leukemia cells, and is fit for the nutraceutical compositions comprising the miRNA
Vittorio Colizzi
European Patent Office (EPO)
9-mar-2016
18-set-2019
EP3216869B1
Settore MED/04 - PATOLOGIA GENERALE
English
plant microRNAs (miRNAs)
mammalian microRNAs (miRNAs)
leukemia
medicinal plants
Olea europea
Moringa oleifera
Colizzi, V; Cirillo, M; Galgani, A; DEL GALLO DI ROCCAGIOVINE, F; Kenzo, M; Minutolo, A; Montesano, C; Muleo, R; Pirrò, S; Potestà, M; Matic, I...espandi
Brevetti
Colizzi, V., Cirillo, M., Galgani, A., DEL GALLO DI ROCCAGIOVINE, F., Kenzo, M., Minutolo, A., et al. (2016). Nutraceutical plant derived microrna elements for treatment of leukemia.
File in questo prodotto:
File Dimensione Formato  
EP3216869B1-2.pdf

solo utenti autorizzati

Tipologia: Altro materiale allegato
Licenza: Copyright dell'editore
Dimensione 711.49 kB
Formato Adobe PDF
711.49 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/322880
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact