Accelerated Long-term Forgetting (ALF) is a memory deficit characterised by normal retention up to relatively short intervals (e.g., minutes, hours) with increased forgetting over longer periods (e.g., days, weeks). ALF is often underestimated due to a lack of common memory assessments beyond 30-60 min. The purpose of this review was to provide an overview of ALF occurrence in neurodegenerative disorders, evaluating whether it can be considered a cognitive deficit useful for diagnosing and monitoring patients. We included 19 experimental studies that investigated ALF in neurodegenerative disorders. Most papers were focused on Alzheimer's disease (AD) dementia and related forms of cognitive decline (Mild Cognitive Impairment, Subjective Cognitive decline, Pre-symptomatic subjects at risk of AD dementia). The major finding of the present work concerns the presence of ALF in very early forms of cognitive decline related to AD. These findings, supporting the hypothesis that ALF is a subtle and undetected hallmark of pre-clinical AD, highlights the importance of investigating forgetting over a longer period and devising standardised measures to be included in clinical practice.

Rodini, M., De Simone, M.s., Caltagirone, C., Carlesimo, G. (2022). Accelerated long-term forgetting in neurodegenerative disorders: A systematic review of the literature. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 141, 1-14 [10.1016/j.neubiorev.2022.104815].

Accelerated long-term forgetting in neurodegenerative disorders: A systematic review of the literature

Carlesimo, Giovanni
2022-10-01

Abstract

Accelerated Long-term Forgetting (ALF) is a memory deficit characterised by normal retention up to relatively short intervals (e.g., minutes, hours) with increased forgetting over longer periods (e.g., days, weeks). ALF is often underestimated due to a lack of common memory assessments beyond 30-60 min. The purpose of this review was to provide an overview of ALF occurrence in neurodegenerative disorders, evaluating whether it can be considered a cognitive deficit useful for diagnosing and monitoring patients. We included 19 experimental studies that investigated ALF in neurodegenerative disorders. Most papers were focused on Alzheimer's disease (AD) dementia and related forms of cognitive decline (Mild Cognitive Impairment, Subjective Cognitive decline, Pre-symptomatic subjects at risk of AD dementia). The major finding of the present work concerns the presence of ALF in very early forms of cognitive decline related to AD. These findings, supporting the hypothesis that ALF is a subtle and undetected hallmark of pre-clinical AD, highlights the importance of investigating forgetting over a longer period and devising standardised measures to be included in clinical practice.
ott-2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Accelerated early-term forgetting
Accelerated long-term forgetting
Alzheimer’s disease
Memory consolidation
Neurodegenerative disorders
Rodini, M., De Simone, M.s., Caltagirone, C., Carlesimo, G. (2022). Accelerated long-term forgetting in neurodegenerative disorders: A systematic review of the literature. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 141, 1-14 [10.1016/j.neubiorev.2022.104815].
Rodini, M; De Simone, Ms; Caltagirone, C; Carlesimo, G
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
Neuroscience and Biobehavioral Reviews - 2022.pdf

solo utenti autorizzati

Tipologia: Versione Editoriale (PDF)
Licenza: Copyright dell'editore
Dimensione 902.24 kB
Formato Adobe PDF
902.24 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/320556
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 9
social impact