The aim of this study was to evaluate the capability and the reliability of diffusion-weighted MR imaging to differentiate benign from malignant renal lesions. Twenty healthy volunteers and 48 patients with known renal lesions underwent MR of the kidneys by using a 1.5 T superconductive magnet. Diffusion-weighted images (DWI) were obtained on the axial plane during breathhold (17 s) with a SE EPI single shot sequence using a b value of 500 s/mm2. One region of interest (ROI) (lesions < than 3 cm) or 3 ROI (lesions > than 3 cm) were placed within the lesion for the measurement of apparent diffusion coefficient (ADC). ADC map was obtained at each slice position. Mean ADC value in normal renal parenchyma was 2.2 +/- 0.20 x 10(-3) mm2/s, while ADC values in simple cysts (n = 20) were higher (mean ADC values 3.65 +/- 0.09 x 10(-3) mm2/s). Solid benign and malignant renal tumors (n = 19) showed a mean ADC value of 1.7 +/- 0.48 x 10(-3) mm2/sec. The comparison between ADC values in normal parenchyma group and tumour group were found to be statistically significant (p < 0.0001). ADC values of cystic renal cell carcinomas were higher than those of clear cell carcinomas (p < 0.001). In conclusion, DW MRI of the kidney seems to be a reliable means for differentiating normal renal parenchyma from different renal tumors.

Squillaci, E., Manenti, G., Di Stefano, F., Miano, R., Strigari, L., Simonetti, G. (2004). Diffusion-weighted MR imaging in the evaluation of renal tumours. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 23(1), 39-45.

Diffusion-weighted MR imaging in the evaluation of renal tumours

SQUILLACI, ETTORE;MANENTI, GUGLIELMO;MIANO, ROBERTO;SIMONETTI, GIOVANNI MARIA EGISTO
2004-03-01

Abstract

The aim of this study was to evaluate the capability and the reliability of diffusion-weighted MR imaging to differentiate benign from malignant renal lesions. Twenty healthy volunteers and 48 patients with known renal lesions underwent MR of the kidneys by using a 1.5 T superconductive magnet. Diffusion-weighted images (DWI) were obtained on the axial plane during breathhold (17 s) with a SE EPI single shot sequence using a b value of 500 s/mm2. One region of interest (ROI) (lesions < than 3 cm) or 3 ROI (lesions > than 3 cm) were placed within the lesion for the measurement of apparent diffusion coefficient (ADC). ADC map was obtained at each slice position. Mean ADC value in normal renal parenchyma was 2.2 +/- 0.20 x 10(-3) mm2/s, while ADC values in simple cysts (n = 20) were higher (mean ADC values 3.65 +/- 0.09 x 10(-3) mm2/s). Solid benign and malignant renal tumors (n = 19) showed a mean ADC value of 1.7 +/- 0.48 x 10(-3) mm2/sec. The comparison between ADC values in normal parenchyma group and tumour group were found to be statistically significant (p < 0.0001). ADC values of cystic renal cell carcinomas were higher than those of clear cell carcinomas (p < 0.001). In conclusion, DW MRI of the kidney seems to be a reliable means for differentiating normal renal parenchyma from different renal tumors.
mar-2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/24 - UROLOGIA
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
English
Con Impact Factor ISI
Magnetic Resonance Imaging; Humans; Aged; Cysts; Carcinoma; Adenocarcinoma, Clear Cell; Kidney Neoplasms; Aged, 80 and over; Adult; Carcinoma, Renal Cell; Kidney; Middle Aged; Diffusion; Kidney Diseases; Time Factors; Image Processing, Computer-Assisted; Male; Female
Squillaci, E., Manenti, G., Di Stefano, F., Miano, R., Strigari, L., Simonetti, G. (2004). Diffusion-weighted MR imaging in the evaluation of renal tumours. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 23(1), 39-45.
Squillaci, E; Manenti, G; Di Stefano, F; Miano, R; Strigari, L; Simonetti, Gme
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/31929
Citazioni
  • ???jsp.display-item.citation.pmc??? 22
  • Scopus 106
  • ???jsp.display-item.citation.isi??? 103
social impact