: We report a 73 years old man with a diagnosis of Paget Disease (PD) and symptomatic Multiple Myeloma (MM). Coexistence of MM and PD has rarely been described. PD mimics many of the features of bone destructive process in MM, making differential diagnosis more complicated. In addition, the presence of serious muscolo-skeletal and metabolic complications in both diseases makes management of patients difficult, worsening the prognosis.The comparison of these two diseases has led to the characterization of a common molecular mechanism represented by the receptor activator of nuclear factor-kB ligand (RANKL)/Osteoprotegerin signaling pathway. The improved comprehension of these mechanisms led to the development of new pharmacologic agents (bisphosphonates, cytokines inhibitors) effective for the treatment of these bone diseases.

Caravita, T., Siniscalchi, A., Montinaro, E., Bove, R., Zaccagnini, M., De Pascalis, D., et al. (2012). Multiple myeloma and paget disease with abnormal skull lesions and intracranial hypertension. MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 4(1) [10.4084/MJHID.2012.068].

Multiple myeloma and paget disease with abnormal skull lesions and intracranial hypertension

Arciprete, F;de Fabritiis, P
2012-01-01

Abstract

: We report a 73 years old man with a diagnosis of Paget Disease (PD) and symptomatic Multiple Myeloma (MM). Coexistence of MM and PD has rarely been described. PD mimics many of the features of bone destructive process in MM, making differential diagnosis more complicated. In addition, the presence of serious muscolo-skeletal and metabolic complications in both diseases makes management of patients difficult, worsening the prognosis.The comparison of these two diseases has led to the characterization of a common molecular mechanism represented by the receptor activator of nuclear factor-kB ligand (RANKL)/Osteoprotegerin signaling pathway. The improved comprehension of these mechanisms led to the development of new pharmacologic agents (bisphosphonates, cytokines inhibitors) effective for the treatment of these bone diseases.
2012
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Caravita, T., Siniscalchi, A., Montinaro, E., Bove, R., Zaccagnini, M., De Pascalis, D., et al. (2012). Multiple myeloma and paget disease with abnormal skull lesions and intracranial hypertension. MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 4(1) [10.4084/MJHID.2012.068].
Caravita, T; Siniscalchi, A; Montinaro, E; Bove, R; Zaccagnini, M; De Pascalis, D; Morocutti, A; Brusa, L; Arciprete, F; Cupini, M; Perrotti, A; Palma...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/319070
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