Breakthrough SARS-CoV-2 infections in fully vaccinated individuals are considered a consequence of waning immunity. Serum antibodies represent the most measurable outcome of vaccine-induced B cell memory. When antibodies decline, memory B cells are expected to persist and perform their function, preventing clinical disease. We investigated whether BNT162b2 mRNA vaccine induces durable and functional B cell memory in vivo against SARS-CoV-2 3, 6, and 9 months after the second dose in a cohort of health care workers (HCWs). While we observed physiological decline of SARS-CoV-2-specific antibodies, memory B cells persist and increase until 9 months after immunization. HCWs with breakthrough infections had no signs of waning immunity. In 3-4 days, memory B cells responded to SARS-CoV-2 infection by producing high levels of specific antibodies in the serum and anti-Spike IgA in the saliva. Antibodies to the viral nucleoprotein were produced with the slow kinetics typical of the response to a novel antigen.

Terreri, S., Mortari, E., Vinci, M., Russo, C., Alteri, C., Albano, C., et al. (2022). Persistent B cell memory after SARS-CoV-2 vaccination is functional during breakthrough infections. CELL HOST & MICROBE, 30(3), 400-408 [10.1016/j.chom.2022.01.003].

Persistent B cell memory after SARS-CoV-2 vaccination is functional during breakthrough infections

Villani, A;
2022-01-01

Abstract

Breakthrough SARS-CoV-2 infections in fully vaccinated individuals are considered a consequence of waning immunity. Serum antibodies represent the most measurable outcome of vaccine-induced B cell memory. When antibodies decline, memory B cells are expected to persist and perform their function, preventing clinical disease. We investigated whether BNT162b2 mRNA vaccine induces durable and functional B cell memory in vivo against SARS-CoV-2 3, 6, and 9 months after the second dose in a cohort of health care workers (HCWs). While we observed physiological decline of SARS-CoV-2-specific antibodies, memory B cells persist and increase until 9 months after immunization. HCWs with breakthrough infections had no signs of waning immunity. In 3-4 days, memory B cells responded to SARS-CoV-2 infection by producing high levels of specific antibodies in the serum and anti-Spike IgA in the saliva. Antibodies to the viral nucleoprotein were produced with the slow kinetics typical of the response to a novel antigen.
2022
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
English
COVID-19; SARS-CoV-2; breakthrough infections; mRNA vaccine; memory B cells; mucosal immunity; salivary IgA; waning immunity
Terreri, S., Mortari, E., Vinci, M., Russo, C., Alteri, C., Albano, C., et al. (2022). Persistent B cell memory after SARS-CoV-2 vaccination is functional during breakthrough infections. CELL HOST & MICROBE, 30(3), 400-408 [10.1016/j.chom.2022.01.003].
Terreri, S; Mortari, E; Vinci, M; Russo, C; Alteri, C; Albano, C; Colavita, F; Gramigna, G; Agrati, C; Linardos, G; Coltella, L; Colagrossi, L; Deriu,...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/317326
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