the burden, microbial etiology and clinical impact of hospital-acquired respiratory infections (HARIs) were determined at an Italian teaching hospital over a 12-month period. for this purpose, overall ordinary hospitalizations >= 2 days of subjects over 18 years old with discharge from 1 january 2018 to 31 december 2018 were examined by cross-referencing demographic and clinical data from hospital discharge forms with microbiological data from the computer system of the microbiology unit. we identified 329 individuals with HARIs (96 females and 233 males; median age 70 years, range 18-93), who represented 1/4 of the total hospital-acquired infections (HAIs) in the period. the inpatient setting was medical and surgical in similar proportions (169 vs. 160, respectively) and the mean hospital stay was 38.9 +/- 33.6 days. one hundred and forty patients (42.6% of the total sample) were suffering from one or more chronic diseases. a total of 581 microorganisms (82 antibiotic-resistant and 499 non-resistant) were detected in HARI patients. the most common isolated species were staphylococcus aureus (16.7%), klebsiella pneumoniae (13.3%), pseudomonas spp. (12.6%) and acinetobacter baumannii (10.5%), followed by enterobacter spp. (5.3%), Escherichia coli (5.2%) and enterococcus spp. (4.8%). one hundred and sixty-seven individuals (49.0% of the total) had polymicrobial infections. one hundred thirty-one patients (39.8% of the total) underwent endotracheal intubation and mechanical ventilation and 62.6% of them died, compared to 17.7% of the non-intubated patients. multivariable analysis confirmed a positive correlation between death and increased age (p = 0.05), surgical MDC (p = 0.007), number of microorganisms over the sample mean (p = 0.001), the presence of chronic diseases (p = 0.046), and intubation and mechanical ventilation (p < 0.0001). a positive correlation between intubation and antibiotic-resistant organisms (p = 0.003) was also found. HARIs are still a major public health problem and require constant surveillance due to their severe clinical outcome.

Maurici, M., D'Alo, G.l., Fontana, C., Santoro, V., Gaziano, R., Ciotti, M., et al. (2022). Microbiology and Clinical Outcome of Hospital-Acquired Respiratory Infections in an Italian Teaching Hospital: A Retrospective Study. HEALTHCARE, 10(11), 1-12 [10.3390/healthcare10112271].

Microbiology and Clinical Outcome of Hospital-Acquired Respiratory Infections in an Italian Teaching Hospital: A Retrospective Study

Maurici M.;Gaziano R.;De Filippis P.;Sarmati L.;Pica F.
2022-11-12

Abstract

the burden, microbial etiology and clinical impact of hospital-acquired respiratory infections (HARIs) were determined at an Italian teaching hospital over a 12-month period. for this purpose, overall ordinary hospitalizations >= 2 days of subjects over 18 years old with discharge from 1 january 2018 to 31 december 2018 were examined by cross-referencing demographic and clinical data from hospital discharge forms with microbiological data from the computer system of the microbiology unit. we identified 329 individuals with HARIs (96 females and 233 males; median age 70 years, range 18-93), who represented 1/4 of the total hospital-acquired infections (HAIs) in the period. the inpatient setting was medical and surgical in similar proportions (169 vs. 160, respectively) and the mean hospital stay was 38.9 +/- 33.6 days. one hundred and forty patients (42.6% of the total sample) were suffering from one or more chronic diseases. a total of 581 microorganisms (82 antibiotic-resistant and 499 non-resistant) were detected in HARI patients. the most common isolated species were staphylococcus aureus (16.7%), klebsiella pneumoniae (13.3%), pseudomonas spp. (12.6%) and acinetobacter baumannii (10.5%), followed by enterobacter spp. (5.3%), Escherichia coli (5.2%) and enterococcus spp. (4.8%). one hundred and sixty-seven individuals (49.0% of the total) had polymicrobial infections. one hundred thirty-one patients (39.8% of the total) underwent endotracheal intubation and mechanical ventilation and 62.6% of them died, compared to 17.7% of the non-intubated patients. multivariable analysis confirmed a positive correlation between death and increased age (p = 0.05), surgical MDC (p = 0.007), number of microorganisms over the sample mean (p = 0.001), the presence of chronic diseases (p = 0.046), and intubation and mechanical ventilation (p < 0.0001). a positive correlation between intubation and antibiotic-resistant organisms (p = 0.003) was also found. HARIs are still a major public health problem and require constant surveillance due to their severe clinical outcome.
12-nov-2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
Settore MED/42
Settore MEDS-03/A - Microbiologia e microbiologia clinica
Settore MEDS-24/B - Igiene generale e applicata
English
antimicrobials
clinical outcome
hospital-acquired respiratory infection (HARI)
hospitalized patients
microorganisms
Maurici, M., D'Alo, G.l., Fontana, C., Santoro, V., Gaziano, R., Ciotti, M., et al. (2022). Microbiology and Clinical Outcome of Hospital-Acquired Respiratory Infections in an Italian Teaching Hospital: A Retrospective Study. HEALTHCARE, 10(11), 1-12 [10.3390/healthcare10112271].
Maurici, M; D'Alo, Gl; Fontana, C; Santoro, V; Gaziano, R; Ciotti, M; Modica, Dc; De Filippis, P; Sarmati, L; De Carolis, G; Pica, F
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
healthcare-10-02271-v2.pdf

accesso aperto

Tipologia: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 338.13 kB
Formato Adobe PDF
338.13 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/317290
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact