Prebiotic chemistry plays a central role in the investigation of the possible scenarios of the early chemical environments. Its goal is to shed light on the events involved in the synthesis of initial biomolecules and on the self-organization processes that led the last common ancestor. Even though a well defined scenario for the physico-chemical conditions on the primitive Earth is not available, one can assume that a synthetic pathway, in order to be considered prebiotic, should use the simplest chemicals and the most common conditions present at that time. Low molecular weight molecules such as hydrogen cyanide and formaldehyde, easily formed from the primitive atmosphere by ultraviolet light, heat or electric discharge as energy sources, have been considered as prebiotic precursors. Here we focus on the attempts to identify the prebiotic events originating purine and pirimidine nucleic acids bases, the necessary components for the assembling of nucleosides, nucleotides and oligonucleotides. © 2004 Bentham Science Publishers Ltd.

Saladino, R., Crestini, C., Costanzo, G., & Di Mauro, E. (2004). Advances in the prebiotic synthesis of nucleic acids bases: Implications for the origin of life. CURRENT ORGANIC CHEMISTRY, 8(15), 1425-1443 [10.2174/1385272043369836].

Advances in the prebiotic synthesis of nucleic acids bases: Implications for the origin of life

CRESTINI, CLAUDIA;
2004

Abstract

Prebiotic chemistry plays a central role in the investigation of the possible scenarios of the early chemical environments. Its goal is to shed light on the events involved in the synthesis of initial biomolecules and on the self-organization processes that led the last common ancestor. Even though a well defined scenario for the physico-chemical conditions on the primitive Earth is not available, one can assume that a synthetic pathway, in order to be considered prebiotic, should use the simplest chemicals and the most common conditions present at that time. Low molecular weight molecules such as hydrogen cyanide and formaldehyde, easily formed from the primitive atmosphere by ultraviolet light, heat or electric discharge as energy sources, have been considered as prebiotic precursors. Here we focus on the attempts to identify the prebiotic events originating purine and pirimidine nucleic acids bases, the necessary components for the assembling of nucleosides, nucleotides and oligonucleotides. © 2004 Bentham Science Publishers Ltd.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore CHIM/03 - Chimica Generale e Inorganica
English
Con Impact Factor ISI
5 methylcytosine; acyclic nucleoside; adenine; adenosine; ammonium formate; formaldehyde; formamide; hydrogen cyanide; hypoxanthine; inosine; inosine phosphate; nitrogen derivative; nucleic acid base; nucleoside derivative; nucleotide; oligonucleotide; polymer; prebiotic agent; purine derivative; pyrimidine derivative; thymine; uracil; uracil derivative; uridine; xanthine; astronomy; chemical reaction; electricity; energy resource; heat; molecular weight; nucleic acid synthesis; physical chemistry; review; ultraviolet radiation
Saladino, R., Crestini, C., Costanzo, G., & Di Mauro, E. (2004). Advances in the prebiotic synthesis of nucleic acids bases: Implications for the origin of life. CURRENT ORGANIC CHEMISTRY, 8(15), 1425-1443 [10.2174/1385272043369836].
Saladino, R; Crestini, C; Costanzo, G; Di Mauro, E
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/31696
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 71
  • ???jsp.display-item.citation.isi??? 72
social impact