T-cell lymphomas and leukemias are highly heterogeneous groups of rare disorders. We report a case of a 68-year-old man patient who developed two different T-cell neoplasms (Large Granular Lymphocyte Leukemia [LGLL] in 2018 and Peripheral T-cell non-Hodgkin lymphoma not otherwise specified [PTCL-NOS] in 2019) with a previous diagnosis of B-cell marginal zone lymphoma in 2010, treated with two lines of chemo-immunotherapy. The coexistence of these different T-cell neoplasms is rarely reported in the literature. Moreover, it is usually described as an LGLL transformation into PTCL-NOS; differently from these examples, herein, the simultaneous conditions appear to be driven by different T-cell clones. Furthermore, the PTCL-NOS had quite unusual behavior, with good disease control without intensive treatment. Because of these features, it could belong to a subgroup of indolent PTCL-NOS, not yet described in the WHO classification of T-cell neoplasms, which could benefit from less aggressive treatment.

Guarnera, L., Boldrini, V., Pasqualone, G., Cimino, C., Meddi, E., Laureana, R., et al. (2022). Coexistence of T-Large Granular Lymphocyte Leukemia and Peripheral T Cell Lymphoma-NOS with Indolent Behavior. MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 14(1), 1-5 [10.4084/MJHID.2022.006].

Coexistence of T-Large Granular Lymphocyte Leukemia and Peripheral T Cell Lymphoma-NOS with Indolent Behavior

Del Poeta, Giovanni;Mauriello, Alessandro;Anemona, Lucia;Postorino, Massimiliano;Cantonetti, Maria
2022-01-01

Abstract

T-cell lymphomas and leukemias are highly heterogeneous groups of rare disorders. We report a case of a 68-year-old man patient who developed two different T-cell neoplasms (Large Granular Lymphocyte Leukemia [LGLL] in 2018 and Peripheral T-cell non-Hodgkin lymphoma not otherwise specified [PTCL-NOS] in 2019) with a previous diagnosis of B-cell marginal zone lymphoma in 2010, treated with two lines of chemo-immunotherapy. The coexistence of these different T-cell neoplasms is rarely reported in the literature. Moreover, it is usually described as an LGLL transformation into PTCL-NOS; differently from these examples, herein, the simultaneous conditions appear to be driven by different T-cell clones. Furthermore, the PTCL-NOS had quite unusual behavior, with good disease control without intensive treatment. Because of these features, it could belong to a subgroup of indolent PTCL-NOS, not yet described in the WHO classification of T-cell neoplasms, which could benefit from less aggressive treatment.
2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15
English
Aggressive T-cell lymphomas
Indolent T-cell lymphomas
LGLL
PTCL-NOS
Guarnera, L., Boldrini, V., Pasqualone, G., Cimino, C., Meddi, E., Laureana, R., et al. (2022). Coexistence of T-Large Granular Lymphocyte Leukemia and Peripheral T Cell Lymphoma-NOS with Indolent Behavior. MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 14(1), 1-5 [10.4084/MJHID.2022.006].
Guarnera, L; Boldrini, V; Pasqualone, G; Cimino, C; Meddi, E; Laureana, R; Trivigno, D; Del Poeta, G; Mauriello, A; Anemona, L; Postorino, M; Cantonetti, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/316764
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