Regulatory T cells (Tregs) are critical modulators of immune homeostasis. Tregs maintain peripheral tolerance to self-antigens, thereby preventing autoimmune disease. Furthermore, Tregs suppress excessive immune responses deleterious to the host. Recent research has deepened our understanding of how Tregs function at the ocular surface. This manuscript describes the classification, the immunosuppressive mechanisms, and the phenotypic plasticity of Tregs. We review the contribution of Tregs to ocular surface autoimmune disease, as well as the function of Tregs in allergy and infection at the ocular surface. Finally, we review the role of Tregs in promoting allotolerance in corneal transplantation. (C) 2017 Elsevier Inc. All rights reserved.

Foulsham, W., Marmalidou, A., Amouzegar, A., Coco, G., Chen, Y., Dana, R. (2017). Review: The function of regulatory T cells at the ocular surface. THE OCULAR SURFACE, 15(4), 652-659 [10.1016/j.jtos.2017.05.013].

Review: The function of regulatory T cells at the ocular surface

Coco, Giulia;
2017-10-01

Abstract

Regulatory T cells (Tregs) are critical modulators of immune homeostasis. Tregs maintain peripheral tolerance to self-antigens, thereby preventing autoimmune disease. Furthermore, Tregs suppress excessive immune responses deleterious to the host. Recent research has deepened our understanding of how Tregs function at the ocular surface. This manuscript describes the classification, the immunosuppressive mechanisms, and the phenotypic plasticity of Tregs. We review the contribution of Tregs to ocular surface autoimmune disease, as well as the function of Tregs in allergy and infection at the ocular surface. Finally, we review the role of Tregs in promoting allotolerance in corneal transplantation. (C) 2017 Elsevier Inc. All rights reserved.
ott-2017
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore MED/30 - MALATTIE APPARATO VISIVO
English
Con Impact Factor ISI
Allergic eye disease
Corneal transplantation
Regulatory T cells
Foulsham, W., Marmalidou, A., Amouzegar, A., Coco, G., Chen, Y., Dana, R. (2017). Review: The function of regulatory T cells at the ocular surface. THE OCULAR SURFACE, 15(4), 652-659 [10.1016/j.jtos.2017.05.013].
Foulsham, W; Marmalidou, A; Amouzegar, A; Coco, G; Chen, Y; Dana, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/316230
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