miRNA detection using microfluidics-based devices is one of the most important innovations in biology and modern medicine. miRNAs are small regulatory molecules, whose varied concentrations can indicate diseases or pathologic conditions, boosting their use as reliable modern biomarkers for advanced medical diagnostics. Due to their small size and low concentration (from femtomolar to picomolar), miRNA measurement is quite challenging. Being rapid and affordable analytical devices for high-throughput quantification of miRNAs, microfluidics-based biosensors are promising. Beside the small volumes of required sample, simple handling, and manipulation of the sample, these tools enable amplification and detection of target miRNA/miRNAs in a single device, overcoming common limitations of conventional methodologies. Herein, we review the recent advancements in microfluidic devices applied for miRNA sample handling, manipulation, and measurement. We also discuss their advantages and limitations as well as future trends in this field.

Khashayar, P., Al-Madhagi, S., Azimzadeh, M., Scognamiglio, V., Arduini, F. (2022). New frontiers in microfluidics devices for miRNA analysis. TRAC. TRENDS IN ANALYTICAL CHEMISTRY, 156 [10.1016/j.trac.2022.116706].

New frontiers in microfluidics devices for miRNA analysis

Fabiana Arduini
2022-06-16

Abstract

miRNA detection using microfluidics-based devices is one of the most important innovations in biology and modern medicine. miRNAs are small regulatory molecules, whose varied concentrations can indicate diseases or pathologic conditions, boosting their use as reliable modern biomarkers for advanced medical diagnostics. Due to their small size and low concentration (from femtomolar to picomolar), miRNA measurement is quite challenging. Being rapid and affordable analytical devices for high-throughput quantification of miRNAs, microfluidics-based biosensors are promising. Beside the small volumes of required sample, simple handling, and manipulation of the sample, these tools enable amplification and detection of target miRNA/miRNAs in a single device, overcoming common limitations of conventional methodologies. Herein, we review the recent advancements in microfluidic devices applied for miRNA sample handling, manipulation, and measurement. We also discuss their advantages and limitations as well as future trends in this field.
16-giu-2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/01 - CHIMICA ANALITICA
Settore CHEM-01/A - Chimica analitica
English
Con Impact Factor ISI
miRNA; Microfluidic; Biosensors; Lab-on-a-chip; miRNA sample preparation
Khashayar, P., Al-Madhagi, S., Azimzadeh, M., Scognamiglio, V., Arduini, F. (2022). New frontiers in microfluidics devices for miRNA analysis. TRAC. TRENDS IN ANALYTICAL CHEMISTRY, 156 [10.1016/j.trac.2022.116706].
Khashayar, P; Al-Madhagi, S; Azimzadeh, M; Scognamiglio, V; Arduini, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/314256
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