Cognitive impairment and malnutrition are prevalent in patients on hemodialysis (HD), and they negatively affect the outcomes of HD patients. Evidence suggests that cognitive impairment and malnutrition may be associated, but clinical studies to assess this association in HD patients are lacking. The aim of this study was to evaluate the association between cognitive impairment evaluated by the Montreal Cognitive Assessment (MoCA) score and nutritional status evaluated by the malnutrition inflammation score (MIS) in HD patients. We enrolled 84 HD patients (44 males and 40 females; age: 75.8 years (63.5–82.7); HD vintage: 46.0 months (22.1–66.9)). The MISs identified 34 patients (40%) as malnourished; the MoCa scores identified 67 patients (80%) with mild cognitive impairment (MCI). Malnourished patients had a higher prevalence of MCI compared to well-nourished patients (85% vs. 70%; p = 0.014). MoCa score and MIS were negatively correlated (rho:−0.317; p < 0.01). Our data showed a high prevalence of MCI and malnutrition in HD patients. Low MoCA scores characterized patients with high MISs, and malnutrition was a risk factor for MCI. In conclusion, it is plausible that MCI and malnutrition are linked by common sociodemographic, clinical, and biochemical risk factors rather than by a pathophysiological mechanism.

Rotondi, S., Tartaglione, L., Pasquali, M., Ceravolo, M.j., Mitterhofer, A.p., Noce, A., et al. (2023). Association between Cognitive Impairment and Malnutrition in Hemodialysis Patients: Two Sides of the Same Coin. NUTRIENTS, 15(4) [10.3390/nu15040813].

Association between Cognitive Impairment and Malnutrition in Hemodialysis Patients: Two Sides of the Same Coin

Mitterhofer, Anna Paola;Noce, Annalisa;Farcomeni, Alessio;
2023-01-01

Abstract

Cognitive impairment and malnutrition are prevalent in patients on hemodialysis (HD), and they negatively affect the outcomes of HD patients. Evidence suggests that cognitive impairment and malnutrition may be associated, but clinical studies to assess this association in HD patients are lacking. The aim of this study was to evaluate the association between cognitive impairment evaluated by the Montreal Cognitive Assessment (MoCA) score and nutritional status evaluated by the malnutrition inflammation score (MIS) in HD patients. We enrolled 84 HD patients (44 males and 40 females; age: 75.8 years (63.5–82.7); HD vintage: 46.0 months (22.1–66.9)). The MISs identified 34 patients (40%) as malnourished; the MoCa scores identified 67 patients (80%) with mild cognitive impairment (MCI). Malnourished patients had a higher prevalence of MCI compared to well-nourished patients (85% vs. 70%; p = 0.014). MoCa score and MIS were negatively correlated (rho:−0.317; p < 0.01). Our data showed a high prevalence of MCI and malnutrition in HD patients. Low MoCA scores characterized patients with high MISs, and malnutrition was a risk factor for MCI. In conclusion, it is plausible that MCI and malnutrition are linked by common sociodemographic, clinical, and biochemical risk factors rather than by a pathophysiological mechanism.
2023
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09 - MEDICINA INTERNA
Settore MED/14 - NEFROLOGIA
Settore SECS-S/01 - STATISTICA
Settore MEDS-05/A - Medicina interna
Settore MEDS-08/B - Nefrologia
Settore STAT-01/A - Statistica
English
https://www.mdpi.com/2072-6643/15/4/813
Rotondi, S., Tartaglione, L., Pasquali, M., Ceravolo, M.j., Mitterhofer, A.p., Noce, A., et al. (2023). Association between Cognitive Impairment and Malnutrition in Hemodialysis Patients: Two Sides of the Same Coin. NUTRIENTS, 15(4) [10.3390/nu15040813].
Rotondi, S; Tartaglione, L; Pasquali, M; Ceravolo, Mj; Mitterhofer, Ap; Noce, A; Tavilla, M; Lai, S; Tinti, F; Muci, Ml; Farcomeni, A; Mazzaferro, S...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/314183
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