It is well documented that COVID-19 vaccines are effective tools for limiting the pandemic. Unfortunately, as is true for all vaccines, SARS-CoV-2 infection in vaccinated individuals is still possible.We present an autopsy case of SARS-CoV-2 infection after vaccination ("breakthrough infection") in an elderly man with several comorbidities where post-mortem CT scan was performed. The death was histologically attributed to cardio-respiratory arrest due to ischemic heart failure related to superinfected COVID-19 pneu-monia and pre-existing comorbidities. For the first time in the literature, PMCT imaging related to a fatal, au-topsy case of breakthrough SARS-CoV-2 infection is reported. PMCT of the lungs, in accordance with histopathological results, showed few signs of COVID-19 pneumonia, large area of consolidation in the right lower lobe, interpreted as bronco-pneumonic focus, and hypostasis.These findings were well-correlated with the previously reported literature about both PMCT and clinical CT imaging of the lungs in non-vaccinated individuals with early COVID-19 pneumonia and about pulmonary clinical CT imaging in COVID-19 pneumonia in breakthrough SARS-COV-2 infections.Further studies are needed to cover the whole spectrum of PMCT lung imaging in fatal breakthrough SARS-CoV-2 infection, however, this case represent a first step for exploring this difficult challenge during SARS-CoV-2 pandemic using virtual autopsy.

Filograna, L., Manenti, G., Grassi, S., Zedda, M., Cazzato, F., Ryan, C.p., et al. (2022). Virtual autopsy in SARS-CoV-2 breakthrough infection: a case report. FORENSIC IMAGING, 30, 1-6 [10.1016/j.fri.2022.200520].

Virtual autopsy in SARS-CoV-2 breakthrough infection: a case report

Manenti G.
Conceptualization
;
Floris R.
Membro del Collaboration Group
;
2022-08-31

Abstract

It is well documented that COVID-19 vaccines are effective tools for limiting the pandemic. Unfortunately, as is true for all vaccines, SARS-CoV-2 infection in vaccinated individuals is still possible.We present an autopsy case of SARS-CoV-2 infection after vaccination ("breakthrough infection") in an elderly man with several comorbidities where post-mortem CT scan was performed. The death was histologically attributed to cardio-respiratory arrest due to ischemic heart failure related to superinfected COVID-19 pneu-monia and pre-existing comorbidities. For the first time in the literature, PMCT imaging related to a fatal, au-topsy case of breakthrough SARS-CoV-2 infection is reported. PMCT of the lungs, in accordance with histopathological results, showed few signs of COVID-19 pneumonia, large area of consolidation in the right lower lobe, interpreted as bronco-pneumonic focus, and hypostasis.These findings were well-correlated with the previously reported literature about both PMCT and clinical CT imaging of the lungs in non-vaccinated individuals with early COVID-19 pneumonia and about pulmonary clinical CT imaging in COVID-19 pneumonia in breakthrough SARS-COV-2 infections.Further studies are needed to cover the whole spectrum of PMCT lung imaging in fatal breakthrough SARS-CoV-2 infection, however, this case represent a first step for exploring this difficult challenge during SARS-CoV-2 pandemic using virtual autopsy.
31-ago-2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/01 - STATISTICA MEDICA
English
SARS-CoV-2 breakthrough infections
COVID-19
PMCT
Virtual autopsy
Vaccination
Filograna, L., Manenti, G., Grassi, S., Zedda, M., Cazzato, F., Ryan, C.p., et al. (2022). Virtual autopsy in SARS-CoV-2 breakthrough infection: a case report. FORENSIC IMAGING, 30, 1-6 [10.1016/j.fri.2022.200520].
Filograna, L; Manenti, G; Grassi, S; Zedda, M; Cazzato, F; Ryan, Cp; Arena, V; Pascali, Vl; Colosimo, C; Floris, R; Oliva, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/313597
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