Recent years have seen continued expansion of the functionality of lab on a chip (LOC) devices. Indeed LOCs now provide scientists and developers with useful and versatile platforms across a myriad of chemical and biological applications. The field still fails, however, to integrate an often important element of bench-top analytics: real-time molecular measurements that can be used to “guide” a chemical response. Here we describe the analytical techniques that could provide LOCs with such real-time molecular monitoring capabilities. It appears to us that, among the approaches that are general (i.e., that are independent of the reactive or optical properties of their targets), sensing strategies relying on binding–induced conformational change of bioreceptors are most likely to succeed in such applications.

Parolo, C., Idili, A., Heikenfeld, J., Plaxco, K.w. (2023). Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices. LAB ON A CHIP [10.1039/D2LC00716A].

Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices

A. Idili
Writing – Original Draft Preparation
;
2023-01-19

Abstract

Recent years have seen continued expansion of the functionality of lab on a chip (LOC) devices. Indeed LOCs now provide scientists and developers with useful and versatile platforms across a myriad of chemical and biological applications. The field still fails, however, to integrate an often important element of bench-top analytics: real-time molecular measurements that can be used to “guide” a chemical response. Here we describe the analytical techniques that could provide LOCs with such real-time molecular monitoring capabilities. It appears to us that, among the approaches that are general (i.e., that are independent of the reactive or optical properties of their targets), sensing strategies relying on binding–induced conformational change of bioreceptors are most likely to succeed in such applications.
19-gen-2023
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/01 - CHIMICA ANALITICA
English
Con Impact Factor ISI
https://pubs.rsc.org/en/content/articlelanding/2023/lc/d2lc00716a/unauth
Parolo, C., Idili, A., Heikenfeld, J., Plaxco, K.w. (2023). Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices. LAB ON A CHIP [10.1039/D2LC00716A].
Parolo, C; Idili, A; Heikenfeld, J; Plaxco, Kw
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/313477
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