Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.
Morante, S., La Penna, G., Rossi, G., Stellato, F. (2020). SARS-CoV-2 virion stabilization by Zn binding. FRONTIERS IN MOLECULAR BIOSCIENCES, 7 [10.3389/fmolb.2020.00222].
SARS-CoV-2 virion stabilization by Zn binding
Morante, SilviaWriting – Original Draft Preparation
;Rossi, GiancarloWriting – Original Draft Preparation
;Stellato, FrancescoInvestigation
2020-01-01
Abstract
Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.| File | Dimensione | Formato | |
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