: Growing evidence suggests that, among the different molecular/cellular pathophysiological mechanisms associated with cancer, there are 14 hallmarks that play a major role, including: (i) sustaining proliferative signaling, (ii) evading growth suppressors, (iii) activating invasion and metastasis, (iv) enabling replicative immortality, (v) inducing angiogenesis, (vi) resisting cell death, (vii) reprogramming energy metabolism, (viii) evading immune destruction, (ix) genome instability and mutations, (x) tumor-promoting inflammation, (xi) unlocking phenotypic plasticity, (xii) nonmutational epigenetic reprogramming, (xiii) polymorphic microbiomes, and (xiv) senescent cells. These hallmarks are also associated with the development of breast cancer, which represents the most prevalent tumor type in the world. The present narrative review aims to describe, for the first time, the effects of physical activity/exercise on these hallmarks. In summary, an active lifestyle, and particularly regular physical exercise, provides beneficial effects on all major hallmarks associated with breast cancer, and might therefore help to counteract the progression of the disease or its associated burden.

Garcia-Chico, C., Lopez-Ortiz, S., Penin-Grandes, S., Pinto-Fraga, J., Valenzuela, P.l., Emanuele, E., et al. (2023). Physical Exercise and the Hallmarks of Breast Cancer: A Narrative Review. CANCERS, 15(1) [10.3390/cancers15010324].

Physical Exercise and the Hallmarks of Breast Cancer: A Narrative Review

Ceci C.;Graziani G.;
2023-01-01

Abstract

: Growing evidence suggests that, among the different molecular/cellular pathophysiological mechanisms associated with cancer, there are 14 hallmarks that play a major role, including: (i) sustaining proliferative signaling, (ii) evading growth suppressors, (iii) activating invasion and metastasis, (iv) enabling replicative immortality, (v) inducing angiogenesis, (vi) resisting cell death, (vii) reprogramming energy metabolism, (viii) evading immune destruction, (ix) genome instability and mutations, (x) tumor-promoting inflammation, (xi) unlocking phenotypic plasticity, (xii) nonmutational epigenetic reprogramming, (xiii) polymorphic microbiomes, and (xiv) senescent cells. These hallmarks are also associated with the development of breast cancer, which represents the most prevalent tumor type in the world. The present narrative review aims to describe, for the first time, the effects of physical activity/exercise on these hallmarks. In summary, an active lifestyle, and particularly regular physical exercise, provides beneficial effects on all major hallmarks associated with breast cancer, and might therefore help to counteract the progression of the disease or its associated burden.
2023
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore BIO/14
English
biomarkers
breast cancer
mammary cancer
physical activity
training
Garcia-Chico, C., Lopez-Ortiz, S., Penin-Grandes, S., Pinto-Fraga, J., Valenzuela, P.l., Emanuele, E., et al. (2023). Physical Exercise and the Hallmarks of Breast Cancer: A Narrative Review. CANCERS, 15(1) [10.3390/cancers15010324].
Garcia-Chico, C; Lopez-Ortiz, S; Penin-Grandes, S; Pinto-Fraga, J; Valenzuela, Pl; Emanuele, E; Ceci, C; Graziani, G; Fiuza-Luces, C; Lista, S; Lucia, A; Santos-Lozano, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/313329
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