Autophagy is important for the degradation of bulk cytoplasm, long-lived proteins, and entire organelles. In lower eukaryotes, autophagy functions as a cell death mechanism or as a stress response during development. However, autophagy's significance in vertebrate development, and the role (if any) of vertebrate-specific factors in its regulation, remains unexplained. Through careful analysis of the current autophagy gene mutant mouse models, we propose that in mammals, autophagy may be involved in specific cytosolic rearrangements needed for proliferation, death, and differentiation during embryogenesis and postnatal development. Thus, autophagy is a process of cytosolic "renovation," crucial in cell fate decisions. © 2008 Elsevier Inc. All rights reserved.

Cecconi, F., Levine, B. (2008). The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death. DEVELOPMENTAL CELL, 15(3), 344-357 [10.1016/j.devcel.2008.08.012].

The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death

CECCONI, FRANCESCO;
2008-01-01

Abstract

Autophagy is important for the degradation of bulk cytoplasm, long-lived proteins, and entire organelles. In lower eukaryotes, autophagy functions as a cell death mechanism or as a stress response during development. However, autophagy's significance in vertebrate development, and the role (if any) of vertebrate-specific factors in its regulation, remains unexplained. Through careful analysis of the current autophagy gene mutant mouse models, we propose that in mammals, autophagy may be involved in specific cytosolic rearrangements needed for proliferation, death, and differentiation during embryogenesis and postnatal development. Thus, autophagy is a process of cytosolic "renovation," crucial in cell fate decisions. © 2008 Elsevier Inc. All rights reserved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/06
English
Con Impact Factor ISI
autophagy; cell death; cell differentiation; cell fate; cell organelle; cell proliferation; cytoplasm; cytosol; degradation; development; embryo development; eukaryote; mammal; mouse mutant; nonhuman; postnatal development; priority journal; protein degradation; regulatory mechanism; review; stress; vertebrate; Animals; Autophagy; Cell Death; Cell Differentiation; Cell Proliferation; Cell Survival; Disease Models, Animal; Humans; Mice; Microtubule-Associated Proteins; Morphogenesis; Phagosomes; Protein Kinases; Proteins; Saccharomyces cerevisiae Proteins; Signal Transduction; Eukaryota; Mammalia; Vertebrata
Cecconi, F., Levine, B. (2008). The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death. DEVELOPMENTAL CELL, 15(3), 344-357 [10.1016/j.devcel.2008.08.012].
Cecconi, F; Levine, B
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/31298
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