The aim of this study was to evaluate the influence of hidden environmental pollution on some blood parameters of sheep to detect susceptible biomarkers able to reveal slight contamination. Four dairy sheep farms, two with semi-extensive and two with intensive type systems were involved in this study. Two farms in different systems were chosen as properly located in a southern area of Latium (Italy), close to the Sacco River, in which contamination with beta-hexachlorocyclohexane (beta-HCH) occurred in the past due to industrial waste. A recent study established the presence of low but detectable residual contamination in these areas. The other two farms were outside the contaminated area. Erythrocyte glutathione transferase (e-GST) and oxidative stress parameters were monitored as well as some immune response and metabolic profile parameters throughout the investigated period of four months. The present study showed a relevant and significant increase in e-GST (+63%) in the extensive farming system of the contaminated area, whereas some immune response biomarkers, i.e., white blood cells, neutrophils, lymphocytes, and lysozyme resulted within the physiological range. In all farms, oxidative stress and acute phase response parameters were also within the physiological range. Our results suggest that e-GST is a very effective alarm signal to reveal "hidden" persistent contamination by beta-HCH, and reasonably, by many other different dangerous pollutants.

Bocedi, A., Lai, O., Cattani, G., Roncoroni, C., Gambardella, G., Notari, S., et al. (2022). Animal biomonitoring for the surveillance of environment affected by the presence of slight contamination by β-HCH. ANTIOXIDANTS, 11(3) [10.3390/antiox11030527].

Animal biomonitoring for the surveillance of environment affected by the presence of slight contamination by β-HCH

Bocedi, Alessio;Ricci, Giorgio
2022-03-10

Abstract

The aim of this study was to evaluate the influence of hidden environmental pollution on some blood parameters of sheep to detect susceptible biomarkers able to reveal slight contamination. Four dairy sheep farms, two with semi-extensive and two with intensive type systems were involved in this study. Two farms in different systems were chosen as properly located in a southern area of Latium (Italy), close to the Sacco River, in which contamination with beta-hexachlorocyclohexane (beta-HCH) occurred in the past due to industrial waste. A recent study established the presence of low but detectable residual contamination in these areas. The other two farms were outside the contaminated area. Erythrocyte glutathione transferase (e-GST) and oxidative stress parameters were monitored as well as some immune response and metabolic profile parameters throughout the investigated period of four months. The present study showed a relevant and significant increase in e-GST (+63%) in the extensive farming system of the contaminated area, whereas some immune response biomarkers, i.e., white blood cells, neutrophils, lymphocytes, and lysozyme resulted within the physiological range. In all farms, oxidative stress and acute phase response parameters were also within the physiological range. Our results suggest that e-GST is a very effective alarm signal to reveal "hidden" persistent contamination by beta-HCH, and reasonably, by many other different dangerous pollutants.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10
English
biomarker
environmental pollution
erythrocyte glutathione transferase
exposure assessment
mammal biomonitoring
oxidative stress
Bocedi, A., Lai, O., Cattani, G., Roncoroni, C., Gambardella, G., Notari, S., et al. (2022). Animal biomonitoring for the surveillance of environment affected by the presence of slight contamination by β-HCH. ANTIOXIDANTS, 11(3) [10.3390/antiox11030527].
Bocedi, A; Lai, O; Cattani, G; Roncoroni, C; Gambardella, G; Notari, S; Tancredi, F; Bitonti, G; Calabrò, S; Ricci, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/312067
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