decades of research have investigated the mechanisms that lead to the origin of cancer, striving to identify tumor-initiating cells. these cells, also known as cancer stem cells, are characterized by the ability to self-renew, to give rise to differentiated tumor populations, and on a larger scale, are deemed responsible not only for tumor initiation but also for recurrent tumors, often resistant to chemotherapy and radiotherapy. Long noncoding RNAs are RNA molecules longer than 200 nt, lacking the ability to code for proteins, with recognized roles as fine regulators of gene expression. They can exert these functions through a variety of mechanisms, acting at almost all steps of gene expression, from modulation of the epigenetic state of chromatin to modulation of protein stability. In all cases, lncRNAs do not work alone, but they always interact with other RNA molecules, either coding or non-coding, or with protein factors. In this review, we summarize the latest results obtained about the involvement of lncRNAs in the initiating cells of several types of tumors, and highlight the different mechanisms through which they work, while discussing how the modulation of a lncRNA can affect several aspects of tumor onset and progression.

Ciafrè, S.a., Russo, M., Michienzi, A., Galardi, S. (2023). Long Noncoding RNAs and Cancer Stem Cells: Dangerous Liaisons Managing Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(3), 1-17 [10.3390/ijms24031828].

Long Noncoding RNAs and Cancer Stem Cells: Dangerous Liaisons Managing Cancer

Ciafrè, Silvia Anna
;
Michienzi, Alessandro;Galardi, Silvia
2023-01-01

Abstract

decades of research have investigated the mechanisms that lead to the origin of cancer, striving to identify tumor-initiating cells. these cells, also known as cancer stem cells, are characterized by the ability to self-renew, to give rise to differentiated tumor populations, and on a larger scale, are deemed responsible not only for tumor initiation but also for recurrent tumors, often resistant to chemotherapy and radiotherapy. Long noncoding RNAs are RNA molecules longer than 200 nt, lacking the ability to code for proteins, with recognized roles as fine regulators of gene expression. They can exert these functions through a variety of mechanisms, acting at almost all steps of gene expression, from modulation of the epigenetic state of chromatin to modulation of protein stability. In all cases, lncRNAs do not work alone, but they always interact with other RNA molecules, either coding or non-coding, or with protein factors. In this review, we summarize the latest results obtained about the involvement of lncRNAs in the initiating cells of several types of tumors, and highlight the different mechanisms through which they work, while discussing how the modulation of a lncRNA can affect several aspects of tumor onset and progression.
gen-2023
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/13 - BIOLOGIA APPLICATA
Settore BIO/11
English
Con Impact Factor ISI
lncRNAs; ceRNAs; RNA-binding protein; cancer stem cells; epigenetic regulation
Ciafrè, S.a., Russo, M., Michienzi, A., Galardi, S. (2023). Long Noncoding RNAs and Cancer Stem Cells: Dangerous Liaisons Managing Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(3), 1-17 [10.3390/ijms24031828].
Ciafrè, Sa; Russo, M; Michienzi, A; Galardi, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/312036
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