Background: Osteoporosis is a serious global health problem for the future, that is why improving diagnostic methods and prevention of this disease could be helpful. Objectives: To assess the effects of calcium supplementations combined with Vitamin D on bone mineral density (BMD) and bone mineral content (BMC) in a representative sample of peri- and post-menopausal women in a double-blind, a randomized, controlled trial was untaken. Design: A total of 120 women aged over 45 were included in a randomised placebo-controlled, double-blind trial on the effect of a daily dietary supplementation of calcium and Vitamin D on bone mineral density and bone mineral content; over a 30-month period. Methods: Dietary intake assessment; dual-energy X-ray absorptiometry to measure total body and segmental bone mineral density and bone mineral content at beginning of the study and every 15 months were undertaken. Results: There was no significant change in dietary calcium or Vitamin D intakes in either of the treatment groups during the 30-month intervention period. The change in total BMD in the calcium group was significantly different from that in the placebo group (P < 0.005). The placebo group lost a total BMD at a rate of about 0.4% per year. There was an inverse correlation between BMD and age. Conclusions: The effect of calcium and Vitamin D supplementation on bone mineral density of calcium has been demonstrated in this group of young adult women. Our results showed the positive effect of calcium and Vitamin D supplementation in women both peri- and post-menopausal status; for this reason a supplementation of calcium and Vitamin D should be recommended as a strategic option in helping to prevent early postmenopausal bone loss. © 2004 Published by Elsevier Ltd.

Di Daniele, N.D., Carbonelli, M.G., Candeloro, N., Iacopino, L., De Lorenzo, A., & Andreoli, A. (2004). Effect of supplementation of calcium and Vitamin D on bone mineral density and bone mineral content in peri- and post-menopause women: A double-blind, randomized, controlled trial. PHARMACOLOGICAL RESEARCH, 50(6), 637-641 [10.1016/j.phrs.2004.05.010].

Effect of supplementation of calcium and Vitamin D on bone mineral density and bone mineral content in peri- and post-menopause women: A double-blind, randomized, controlled trial

DI DANIELE, NICOLA;CANDELORO, NICOLA;IACOPINO, LEONARDO;DE LORENZO, ANTONINO;ANDREOLI, ANGELA
2004

Abstract

Background: Osteoporosis is a serious global health problem for the future, that is why improving diagnostic methods and prevention of this disease could be helpful. Objectives: To assess the effects of calcium supplementations combined with Vitamin D on bone mineral density (BMD) and bone mineral content (BMC) in a representative sample of peri- and post-menopausal women in a double-blind, a randomized, controlled trial was untaken. Design: A total of 120 women aged over 45 were included in a randomised placebo-controlled, double-blind trial on the effect of a daily dietary supplementation of calcium and Vitamin D on bone mineral density and bone mineral content; over a 30-month period. Methods: Dietary intake assessment; dual-energy X-ray absorptiometry to measure total body and segmental bone mineral density and bone mineral content at beginning of the study and every 15 months were undertaken. Results: There was no significant change in dietary calcium or Vitamin D intakes in either of the treatment groups during the 30-month intervention period. The change in total BMD in the calcium group was significantly different from that in the placebo group (P < 0.005). The placebo group lost a total BMD at a rate of about 0.4% per year. There was an inverse correlation between BMD and age. Conclusions: The effect of calcium and Vitamin D supplementation on bone mineral density of calcium has been demonstrated in this group of young adult women. Our results showed the positive effect of calcium and Vitamin D supplementation in women both peri- and post-menopausal status; for this reason a supplementation of calcium and Vitamin D should be recommended as a strategic option in helping to prevent early postmenopausal bone loss. © 2004 Published by Elsevier Ltd.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
English
bone mineral content; bone mineral density; calcium; peri-menopause; post-menopause; vitamin D; analysis of variance; middle aged; postmenopause; female; perimenopause; osteoporosis, postmenopausal; double-blind method; calcium, dietary; bone density; drug combinations; dietary supplements
Di Daniele, N.D., Carbonelli, M.G., Candeloro, N., Iacopino, L., De Lorenzo, A., & Andreoli, A. (2004). Effect of supplementation of calcium and Vitamin D on bone mineral density and bone mineral content in peri- and post-menopause women: A double-blind, randomized, controlled trial. PHARMACOLOGICAL RESEARCH, 50(6), 637-641 [10.1016/j.phrs.2004.05.010].
DI DANIELE, N; Carbonelli, M; Candeloro, N; Iacopino, L; DE LORENZO, A; Andreoli, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/31170
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