Aim: Individuals with high 1-hour post-load glucose (1-h PG > 155 mg/dl; 8.6 mmol/l) during an oral glucose tolerance test are at increased risk of type 2 diabetes (T2D) and cardiovascular complications, hepatic steatosis, and mortality. However, the clinical relevance of 1-h PG for the severity of hepatic fibrosis risk remains undefined.Methods: Cross-sectional data of the CATAMERI study (n = 2335) were analyzed. Participants underwent anthropometric measurements, liver enzyme determinations, cardiometabolic profiling, and a 75-gram oral glucose tolerance test, including fasting, 1-h and 2-h PG determinations and measurement of FIB-4 score to assess degree of hepatic fibrosis. Multivariable logistic regression analysis was performed to evaluate risk of advanced hepatic fibrosis with worsening glycemic status.Results: We stratified the study group into 6 categories based on glycemic status: normal glucose tolerance (NGT) 1h-PG Low, NGT 1h-PG High, iIFG 1h-PG Low, iIFG 1h-PG High, IGT, and newly detected T2D. Anthropometric and cardiometabolic profiles worsened gradually with glycemic status. Moreover, compared to NGT-1h-PG Low group, worsening glycemic status was significantly associated with the severity of fibrosis, independent of other significant clinical risk factors.Conclusions: 1-PG is a valuable tool for stratifying subjects with NGT or IFG at heightened risk of hepatic fibrosis requiring further evaluation with elastography.

Jagannathan, R., Fiorentino, T.v., Marini, M.a., Sesti, G., Bergman, M. (2022). One-hour post-load glucose is associated with severity of hepatic fibrosis risk. DIABETES RESEARCH AND CLINICAL PRACTICE, 189, 109977 [10.1016/j.diabres.2022.109977].

One-hour post-load glucose is associated with severity of hepatic fibrosis risk

Marini, Maria Adelaide
Membro del Collaboration Group
;
2022-07-01

Abstract

Aim: Individuals with high 1-hour post-load glucose (1-h PG > 155 mg/dl; 8.6 mmol/l) during an oral glucose tolerance test are at increased risk of type 2 diabetes (T2D) and cardiovascular complications, hepatic steatosis, and mortality. However, the clinical relevance of 1-h PG for the severity of hepatic fibrosis risk remains undefined.Methods: Cross-sectional data of the CATAMERI study (n = 2335) were analyzed. Participants underwent anthropometric measurements, liver enzyme determinations, cardiometabolic profiling, and a 75-gram oral glucose tolerance test, including fasting, 1-h and 2-h PG determinations and measurement of FIB-4 score to assess degree of hepatic fibrosis. Multivariable logistic regression analysis was performed to evaluate risk of advanced hepatic fibrosis with worsening glycemic status.Results: We stratified the study group into 6 categories based on glycemic status: normal glucose tolerance (NGT) 1h-PG Low, NGT 1h-PG High, iIFG 1h-PG Low, iIFG 1h-PG High, IGT, and newly detected T2D. Anthropometric and cardiometabolic profiles worsened gradually with glycemic status. Moreover, compared to NGT-1h-PG Low group, worsening glycemic status was significantly associated with the severity of fibrosis, independent of other significant clinical risk factors.Conclusions: 1-PG is a valuable tool for stratifying subjects with NGT or IFG at heightened risk of hepatic fibrosis requiring further evaluation with elastography.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/09
English
1-h Post load glucose
FIB-4
Hepatic fibrosis
Oral glucose tolerance test
Jagannathan, R., Fiorentino, T.v., Marini, M.a., Sesti, G., Bergman, M. (2022). One-hour post-load glucose is associated with severity of hepatic fibrosis risk. DIABETES RESEARCH AND CLINICAL PRACTICE, 189, 109977 [10.1016/j.diabres.2022.109977].
Jagannathan, R; Fiorentino, Tv; Marini, Ma; Sesti, G; Bergman, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/311238
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