Proliferating cell nuclear antigen (PCNA) is essential for DNA replication of mammalian cells and their small DNA tumour viruses. The E7 oncoprotein of high-risk human papillomavirus (HPV) is known to activate PCNA, shown to be up-regulated in CIN and cervical cancer (CC), but still incompletely studied as an intermediate endpoint marker in this disease.

Branca, M., Ciotti, M., Giorgi, C., Santini, D., Di Bonito, L., Costa, S., et al. (2007). Up-regulation of proliferating cell nuclear antigen (PCNA) is closely associated with high-risk human papillomavirus (HPV) and progression of cervical intraepithelial neoplasia (CIN), but does not predict disease outcome in cervical cancer. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY, 130(2), 223-231 [10.1016/j.ejogrb.2006.10.007].

Up-regulation of proliferating cell nuclear antigen (PCNA) is closely associated with high-risk human papillomavirus (HPV) and progression of cervical intraepithelial neoplasia (CIN), but does not predict disease outcome in cervical cancer

COSTA, STEFANO;FAVALLI, CARTESIO;
2007-02-01

Abstract

Proliferating cell nuclear antigen (PCNA) is essential for DNA replication of mammalian cells and their small DNA tumour viruses. The E7 oncoprotein of high-risk human papillomavirus (HPV) is known to activate PCNA, shown to be up-regulated in CIN and cervical cancer (CC), but still incompletely studied as an intermediate endpoint marker in this disease.
feb-2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Proliferating Cell Nuclear Antigen; Humans; Tumor Virus Infections; Prognosis; Disease Progression; Papillomaviridae; Aged; Predictive Value of Tests; Conization; Cervical Intraepithelial Neoplasia; Uterine Cervical Neoplasms; Cervix Uteri; Aged, 80 and over; Adult; Papillomavirus Infections; Middle Aged; Up-Regulation; Adolescent; Carcinoma, Squamous Cell; Immunohistochemistry; Tumor Markers, Biological; Cell Cycle; Female; DNA Probes, HPV
Branca, M., Ciotti, M., Giorgi, C., Santini, D., Di Bonito, L., Costa, S., et al. (2007). Up-regulation of proliferating cell nuclear antigen (PCNA) is closely associated with high-risk human papillomavirus (HPV) and progression of cervical intraepithelial neoplasia (CIN), but does not predict disease outcome in cervical cancer. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY, 130(2), 223-231 [10.1016/j.ejogrb.2006.10.007].
Branca, M; Ciotti, M; Giorgi, C; Santini, D; Di Bonito, L; Costa, S; Benedetto, A; Bonifacio, D; Di Bonito, P; Paba, P; Accardi, L; Syrjänen, S; Favalli, C; Syrjänen, K
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/31068
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