The main mechanism underlying cancer dissemination is the epithelial to mesenchymal transition (EMT). This process is orchestrated by cytokines like TGFβ, involving "non-canonical" AKT- or STAT3-driven pathways. Recently, the alteration of copper homeostasis seems involved in the onset and progression of cancer.
Vitaliti, A., Roccatani, I., Iorio, E., Perta, N., Gismondi, A., Chirico, M., et al. (2023). AKT-driven epithelial-mesenchymal transition is affected by copper bioavailability in HER2 negative breast cancer cells via a LOXL2-independent mechanism. CELLULAR ONCOLOGY, 46, 93-115 [10.1007/s13402-022-00738-w].
AKT-driven epithelial-mesenchymal transition is affected by copper bioavailability in HER2 negative breast cancer cells via a LOXL2-independent mechanism
Iorio, Egidio;Gismondi, Angelo;Di Marino, Daniele;Canini, Antonella;De Luca, Anastasia
;Rossi, Luisa
2023-01-01
Abstract
The main mechanism underlying cancer dissemination is the epithelial to mesenchymal transition (EMT). This process is orchestrated by cytokines like TGFβ, involving "non-canonical" AKT- or STAT3-driven pathways. Recently, the alteration of copper homeostasis seems involved in the onset and progression of cancer.| File | Dimensione | Formato | |
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AKT‑driven epithelial‑mesenchymal transition is afected.pdf
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