The main mechanism underlying cancer dissemination is the epithelial to mesenchymal transition (EMT). This process is orchestrated by cytokines like TGFβ, involving "non-canonical" AKT- or STAT3-driven pathways. Recently, the alteration of copper homeostasis seems involved in the onset and progression of cancer.

Vitaliti, A., Roccatani, I., Iorio, E., Perta, N., Gismondi, A., Chirico, M., et al. (2022). AKT-driven epithelial-mesenchymal transition is affected by copper bioavailability in HER2 negative breast cancer cells via a LOXL2-independent mechanism. CELLULAR ONCOLOGY [10.1007/s13402-022-00738-w].

AKT-driven epithelial-mesenchymal transition is affected by copper bioavailability in HER2 negative breast cancer cells via a LOXL2-independent mechanism

Iorio, Egidio;Gismondi, Angelo;Di Marino, Daniele;Canini, Antonella;De Luca, Anastasia
;
Rossi, Luisa
2022-12-01

Abstract

The main mechanism underlying cancer dissemination is the epithelial to mesenchymal transition (EMT). This process is orchestrated by cytokines like TGFβ, involving "non-canonical" AKT- or STAT3-driven pathways. Recently, the alteration of copper homeostasis seems involved in the onset and progression of cancer.
1-dic-2022
Online ahead of print
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA
English
AKT; Breast cancer; Copper; Epithelial to mesenchymal transition; HER2; LOXL2; TGFβ; TRIEN
Vitaliti, A., Roccatani, I., Iorio, E., Perta, N., Gismondi, A., Chirico, M., et al. (2022). AKT-driven epithelial-mesenchymal transition is affected by copper bioavailability in HER2 negative breast cancer cells via a LOXL2-independent mechanism. CELLULAR ONCOLOGY [10.1007/s13402-022-00738-w].
Vitaliti, A; Roccatani, I; Iorio, E; Perta, N; Gismondi, A; Chirico, M; Pisanu, Me; Di Marino, D; Canini, A; De Luca, A; Rossi, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/309755
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