Dendritic cells (DCs) show a remarkable functional plasticity in the recognition of Aspergillus fumigatus and orchestrate the antifungal immune resistance in the lungs. Here, we show that thymosin alpha1, a naturally occurring thymic peptide, induces functional maturation and interleukin-12 production by fungus-pulsed DCs through the 038 mitogen-activated protein kinase/ nuclear factor (NF)-kappaB-dependent path-way. This occurs by signaling through the myeloid differentiation factor 88-dependent pathway, involving distinct Toll-like receptors. In vivo, the synthetic peptide activates T-helper (Th) cell 1-dependent antifungal immunity, accelerates myeloid cell recovery, and protects highly susceptible mice that received hematopoietic transplants from aspergillosis. By revealing the unexpected activity of an old molecule, our finding provides the rationale for its therapeutic utility and qualify the synthetic peptide as a candidate adjuvant promoting the coordinated activation of the innate and adaptive Th immunity to the fungus. (C) 2004 by The American Society of Hematology.
Romani, L., Bistoni, F., Gaziano, R., Bozza, S., Montagnoli, C., Perruccio, K., et al. (2004). Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through Toll-like receptor signaling. BLOOD, 4232-4239.
Tipologia: | Articolo su rivista |
Citazione: | Romani, L., Bistoni, F., Gaziano, R., Bozza, S., Montagnoli, C., Perruccio, K., et al. (2004). Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through Toll-like receptor signaling. BLOOD, 4232-4239. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/07 - Microbiologia e Microbiologia Clinica |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1182/blood-2003-11-4036 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2004 |
Titolo: | Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through Toll-like receptor signaling |
Autori: | |
Autori: | Romani, L; Bistoni, F; Gaziano, R; Bozza, S; Montagnoli, C; Perruccio, K; Pitzurra, L; Bellocchio, S; Velardi, A; Rasi, G; di Francesco, P; Garaci, E |
Appare nelle tipologie: | 01 - Articolo su rivista |