Objective: To test the hypothesis that infection with virulent cytotoxin-associated gene-A (CagA)-bearing Helicobacter pylori strains influences the atherosclerotic process and the clinical course in atherosclerotic stroke patients. Methods: ELISA was used to assess the seroprevalence of infection by H. pylori and CagA-positive strains in 185 patients. Intima-media thickness (IMT) was determined by Doppler ultrasound. Baseline, 1-week, and 1-month NIH Stroke Scale (NIHSS) scores were used to evaluate the short-term clinical course. Results: H. pylori infection was found in 79% of patients; 58% of these tested positive for CagA. IMT was higher among CagA-positive patients than among CagA-negative ones (1.13 +/- 0.26 mm vs 0.97 +/- 0.15 mm; univariate analysis, p = 0.0001; multivariate analysis, odds ratio [ OR], 2.36; 95% CI, 1.57 to 3.54; p = 0.0001) or H. pylori-negative ones ( 1.01 +/- 0.17 mm; univariate analysis, p = 0.007; multivariate analysis, OR, 1.90; 95% CI, 1.22 to 2.97; p = 0.005). CagA-positive patients had poorer initial outcomes based on serial measurements of the NIHSS score ( repeated measures analysis of variance, p < 0.0001). No significant difference in IMT and NIHSS score was found between H. pylori-positive and H. pylori-negative patients. Conclusions: Infection with cytotoxin-associated gene-A-positive Helicobacter pylori strains in atherosclerotic stroke patients is associated with greater intima-media thickness and poorer short-term outcome compared with cytotoxin-associated gene-A-negative patients.
Diomedi, M., Pietroiusti, A., Silvestrini, M., Rizzato, B., Cupini, L.M., Ferrante, F., et al. (2004). CagA-positive Helicobacter pylori strains may influence the natural history of atherosclerotic stroke. NEUROLOGY, 63(5), 800-804.
|Tipologia:||Articolo su rivista|
|Citazione:||Diomedi, M., Pietroiusti, A., Silvestrini, M., Rizzato, B., Cupini, L.M., Ferrante, F., et al. (2004). CagA-positive Helicobacter pylori strains may influence the natural history of atherosclerotic stroke. NEUROLOGY, 63(5), 800-804.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
Settore MED/44 - Medicina del Lavoro
|Revisione (peer review):||Sì, ma tipo non specificato|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||set-2004|
|Titolo:||CagA-positive Helicobacter pylori strains may influence the natural history of atherosclerotic stroke|
|Autori:||Diomedi, M; Pietroiusti, A; Silvestrini, M; Rizzato, B; Cupini, LM; Ferrante, F; Magrini, A; Bergamaschi, A; Galante, A; Bernardi G.|
|Appare nelle tipologie:||01 - Articolo su rivista|