Introduction Previous observation identified both hypotension and arterial aging, indexed as Pulse Wave Velocity (PWV), as significant determinants of cognitive decline in older subjects. Aim To investigate the role of PWV as a determinant of hypotension in older patients. Methods A cohort of 344 subjects came to our Outpatient Clinic, free of cancer, acute myocardial infarction or stroke, atrial fibrillation, renal, hepatic or cardiac failure, secondary hypertension, or thyroid disease. Results Hypotension occurred in 49% of participants. SBP levels (OR 0.79, 95% CI 0.67-0.84, p < 0.01), PWV (OR 0.86, 95% CI 0.77-0.94, p < 0.01), and use of beta-blockers (OR 2.42, 95% CI 1.09-5.36, p < 0.05), were independent determinants of the risk of hypotension. Conclusions Hypotension is a quite common phenomenon in older subjects. Its prevention requires a more accurate management of hypertension aimed at better identifying which older subjects in whom intensive BP control may be harmful and those who may benefit from it.

Rovella, V., DI MARCO, G., Sali, E., Barnett, O., Scuteri, A., Di Daniele, N. (2020). Is Arterial Stiffness a Determinant of Hypotension?. HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION, 27(4), 315-320 [10.1007/s40292-020-00388-9].

Is Arterial Stiffness a Determinant of Hypotension?

Rovella, Valentina;Gabriele, Marco;Di Daniele, Nicola
2020-08-01

Abstract

Introduction Previous observation identified both hypotension and arterial aging, indexed as Pulse Wave Velocity (PWV), as significant determinants of cognitive decline in older subjects. Aim To investigate the role of PWV as a determinant of hypotension in older patients. Methods A cohort of 344 subjects came to our Outpatient Clinic, free of cancer, acute myocardial infarction or stroke, atrial fibrillation, renal, hepatic or cardiac failure, secondary hypertension, or thyroid disease. Results Hypotension occurred in 49% of participants. SBP levels (OR 0.79, 95% CI 0.67-0.84, p < 0.01), PWV (OR 0.86, 95% CI 0.77-0.94, p < 0.01), and use of beta-blockers (OR 2.42, 95% CI 1.09-5.36, p < 0.05), were independent determinants of the risk of hypotension. Conclusions Hypotension is a quite common phenomenon in older subjects. Its prevention requires a more accurate management of hypertension aimed at better identifying which older subjects in whom intensive BP control may be harmful and those who may benefit from it.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09
Settore MED/49
English
Arterial stiffness
Blood pressure
Hypotension
Pulse wave velocity
Adrenergic beta-Antagonists
Age Factors
Aged
Aged, 80 and over
Female
Humans
Hypotension
Male
Middle Aged
Pulse Wave Analysis
Risk Assessment
Risk Factors
Aging
Arterial Pressure
Vascular Stiffness
Rovella, V., DI MARCO, G., Sali, E., Barnett, O., Scuteri, A., Di Daniele, N. (2020). Is Arterial Stiffness a Determinant of Hypotension?. HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION, 27(4), 315-320 [10.1007/s40292-020-00388-9].
Rovella, V; DI MARCO, G; Sali, E; Barnett, O; Scuteri, A; Di Daniele, N
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/308683
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