Objective: To investigate the role of the HS1.2 enhancer polymorphisms as a new candidate marker for rheumatoid arthritis (RA) and to define the possible association with autoantibody positivity and clinical outcome. Methods: Genomic DNA was obtained from two cohorts of patients with RA (100 with early RA (ERA) and 114 with longstanding RA (LSRA)) and from 248 gender-matched controls from the same geographical area. Clinical and immunological characteristics were recorded for all the patients. Results: The percentage of the 2/2 genotype was higher In patients with ERA (27.0%), and In patients with LSRA (34.2%), than In controls (14.9%) (ERA: OR = 2.11 (95% Cl 1.20 to 3.70) vs controls; LSRA: OR = 2.96 (95% Cl 1.76 to 5.00) vs controls). A lower representation of allele *3 was present In patients with ERA (2.0%) than In controls (6.0%; OR = 0.32 (95% Cl 0.11 to 0.91)). No significant associations were found between polymorphisms and autoantibodies positivity. Conclusion: The HS1.2A allele *2 associates with early and longstanding RA.

Tolusso, B., Frezza, D., Mattioli, C., Fedele, A.L., Bosello, S., Faustini, F., et al. (2009). Allele *2 of the HS1,2A enhancer of the Ig regulatory region associates with rheumatoid arthritis. ANNALS OF THE RHEUMATIC DISEASES, 68(3), 416-419 [10.1136/ard.2008.095414].

Allele *2 of the HS1,2A enhancer of the Ig regulatory region associates with rheumatoid arthritis

FREZZA, DOMENICO;
2009

Abstract

Objective: To investigate the role of the HS1.2 enhancer polymorphisms as a new candidate marker for rheumatoid arthritis (RA) and to define the possible association with autoantibody positivity and clinical outcome. Methods: Genomic DNA was obtained from two cohorts of patients with RA (100 with early RA (ERA) and 114 with longstanding RA (LSRA)) and from 248 gender-matched controls from the same geographical area. Clinical and immunological characteristics were recorded for all the patients. Results: The percentage of the 2/2 genotype was higher In patients with ERA (27.0%), and In patients with LSRA (34.2%), than In controls (14.9%) (ERA: OR = 2.11 (95% Cl 1.20 to 3.70) vs controls; LSRA: OR = 2.96 (95% Cl 1.76 to 5.00) vs controls). A lower representation of allele *3 was present In patients with ERA (2.0%) than In controls (6.0%; OR = 0.32 (95% Cl 0.11 to 0.91)). No significant associations were found between polymorphisms and autoantibodies positivity. Conclusion: The HS1.2A allele *2 associates with early and longstanding RA.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/18 - Genetica
eng
Con Impact Factor ISI
autoantibody; etanercept; genomic DNA; immunoglobulin; methotrexate; tumor necrosis factor inhibitor; antirheumatic agent; HS1,2 A enhancer protein, human; HS1,2-A enhancer protein, human; immunoglobulin heavy chain; rheumatoid factor; adult; allele; article; cohort analysis; controlled study; disease activity; DNA polymorphism; enhancer region; enzyme linked immunosorbent assay; female; gene frequency; genetic association; genotype; human; immune response; immunogenetics; major clinical study; male; marker gene; priority journal; rheumatoid arthritis; sex determination; treatment duration; aged; blood; genetic marker; genetic predisposition; genetics; hospitalization; immunology; middle aged; phenotype; regulatory sequence; treatment outcome; Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Cohort Studies; Enhancer Elements, Genetic; Female; Genetic Markers; Genetic Predisposition to Disease; Genotype; Humans; Immunoglobulin Heavy Chains; Male; Middle Aged; Phenotype; Regulatory Sequences, Nucleic Acid; Rheumatoid Factor; Severity of Illness Index; Treatment Outcome
articolo scientifico sperimentale
Tolusso, B., Frezza, D., Mattioli, C., Fedele, A.L., Bosello, S., Faustini, F., et al. (2009). Allele *2 of the HS1,2A enhancer of the Ig regulatory region associates with rheumatoid arthritis. ANNALS OF THE RHEUMATIC DISEASES, 68(3), 416-419 [10.1136/ard.2008.095414].
Tolusso, B; Frezza, D; Mattioli, C; Fedele, A; Bosello, S; Faustini, F; Peluso, G; Giambra, V; Pietrapertosa, D; Morelli, A; Gremese, E; De Santis, M; Ferraccioli, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/30831
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