Transforming small-molecule antibiotics into carrier-free nanoantibiotics represents an opportunity for developing new multifunctional therapeutic agents. In this study, we demonstrate that acoustic cavitation produced by high-frequency ultrasound transforms the antibiotic doxycycline into carrier-free nanobiotics. Upon sonication for 1 h at 10-15 W cm(-3), doxycycline molecules underwent hydroxylation and dimerization processes to ulti-mately self-assemble into nanoparticles of ~100-200 nm in size. Micrometer sized particles can be also obtained by increasing the acoustic power to 20 W cm(-3). The nanodrugs exhibited antioxidant properties, along with antimicrobial activity against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacterial strains. Our results highlight the feasibility of the ultrasound-based approach for engineering drug molecules into a nanosized formulation with controlled and multiple bio-functionalities.
Zhu, H., Wen, Q., Bhangu, S.k., Ashokkumar, M., Cavalieri, F. (2022). Sonosynthesis of nanobiotics with antimicrobial and antioxidant properties. ULTRASONICS SONOCHEMISTRY, 86 [10.1016/j.ultsonch.2022.106029].
Sonosynthesis of nanobiotics with antimicrobial and antioxidant properties
Cavalieri, Francesca
2022-05-01
Abstract
Transforming small-molecule antibiotics into carrier-free nanoantibiotics represents an opportunity for developing new multifunctional therapeutic agents. In this study, we demonstrate that acoustic cavitation produced by high-frequency ultrasound transforms the antibiotic doxycycline into carrier-free nanobiotics. Upon sonication for 1 h at 10-15 W cm(-3), doxycycline molecules underwent hydroxylation and dimerization processes to ulti-mately self-assemble into nanoparticles of ~100-200 nm in size. Micrometer sized particles can be also obtained by increasing the acoustic power to 20 W cm(-3). The nanodrugs exhibited antioxidant properties, along with antimicrobial activity against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacterial strains. Our results highlight the feasibility of the ultrasound-based approach for engineering drug molecules into a nanosized formulation with controlled and multiple bio-functionalities.File | Dimensione | Formato | |
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