Gene silencing induced by RNAi represents a promising antiviral development strategy. This review will summarise the current state of RNAi therapeutics for treating acute and chronic human virus infections. The gene silencing pathways exploited by RNAi therapeutics will be described and include both classic RNAi, inducing cytoplasmic mRNA degradation post-transcription and novel RNAi, mediating epigenetic modifications at the transcription level in the nucleus. Finally, the challenge of delivering gene modifications via RNAi will be discussed, along with the unique characteristics of respiratory versus systemic administration routes to highlight recent advances and future potential of RNAi antiviral treatment strategies.

Kelleher, A.d., Cortez-Jugo, C., Cavalieri, F., Qu, Y., Glanville, A.r., Caruso, F., et al. (2020). RNAi therapeutics: an antiviral strategy for human infections. CURRENT OPINION IN PHARMACOLOGY, 54, 121-129 [10.1016/j.coph.2020.09.011].

RNAi therapeutics: an antiviral strategy for human infections

Cavalieri, Francesca;
2020

Abstract

Gene silencing induced by RNAi represents a promising antiviral development strategy. This review will summarise the current state of RNAi therapeutics for treating acute and chronic human virus infections. The gene silencing pathways exploited by RNAi therapeutics will be described and include both classic RNAi, inducing cytoplasmic mRNA degradation post-transcription and novel RNAi, mediating epigenetic modifications at the transcription level in the nucleus. Finally, the challenge of delivering gene modifications via RNAi will be discussed, along with the unique characteristics of respiratory versus systemic administration routes to highlight recent advances and future potential of RNAi antiviral treatment strategies.
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore CHIM/02
English
Acute Disease
Animals
Chronic Disease
Humans
RNA Interference
Virus Diseases
RNAi Therapeutics
Kelleher, A.d., Cortez-Jugo, C., Cavalieri, F., Qu, Y., Glanville, A.r., Caruso, F., et al. (2020). RNAi therapeutics: an antiviral strategy for human infections. CURRENT OPINION IN PHARMACOLOGY, 54, 121-129 [10.1016/j.coph.2020.09.011].
Kelleher, Ad; Cortez-Jugo, C; Cavalieri, F; Qu, Y; Glanville, Ar; Caruso, F; Symonds, G; Ahlenstiel, Cl
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/308182
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