Neutrophils play a crucial role in the control of the Aspergillus fumigatus infection and act in concert with antifungal drugs. This study was undertaken to obtain insights into the possible involvement of Toll-like receptors (TLRs) in the interaction of liposomal amphotericin B (L-AmB; AmBisome) with neutrophils in response to A. fumigatus.

Bellocchio, S., Gaziano, R., Bozza, S., Rossi, G., Montagnoli, C., Perruccio, K., et al. (2005). Liposomal amphotericin B activates antifungal resistance with reduced toxicity by diverting Toll-like receptor signalling from TLR-2 to TLR-4. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 55(2), 214-222 [10.1093/jac/dkh542].

Liposomal amphotericin B activates antifungal resistance with reduced toxicity by diverting Toll-like receptor signalling from TLR-2 to TLR-4

GAZIANO, ROBERTA;
2005-02-01

Abstract

Neutrophils play a crucial role in the control of the Aspergillus fumigatus infection and act in concert with antifungal drugs. This study was undertaken to obtain insights into the possible involvement of Toll-like receptors (TLRs) in the interaction of liposomal amphotericin B (L-AmB; AmBisome) with neutrophils in response to A. fumigatus.
feb-2005
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Neutrophils; Drug Resistance, Fungal; Female; Liposomes; Toll-Like Receptor 4; Animals; Receptors, Cell Surface; Humans; Toll-Like Receptor 2; Antifungal Agents; Amphotericin B; Mice; Mice, Inbred C57BL; Mice, Inbred BALB C
Bellocchio, S., Gaziano, R., Bozza, S., Rossi, G., Montagnoli, C., Perruccio, K., et al. (2005). Liposomal amphotericin B activates antifungal resistance with reduced toxicity by diverting Toll-like receptor signalling from TLR-2 to TLR-4. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 55(2), 214-222 [10.1093/jac/dkh542].
Bellocchio, S; Gaziano, R; Bozza, S; Rossi, G; Montagnoli, C; Perruccio, K; Calvitti, M; Pitzurra, L; Romani, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/30788
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