Although a growing body of evidence demonstrates that altered mtDNA content (mtDNAc) has clinical implications in several types of solid tumours, its prognostic relevance in acute promyelocytic leukaemia (APL) patients remains largely unknown. Here, we show that patients with higher-than-normal mtDNAc had better outcomes regardless of tumour burden. These results were more evident in patients with low-risk of relapse. The multivariate Cox proportional hazard model demonstrated that high mtDNAc was independently associated with a decreased cumulative incidence of relapse. Altogether, our data highlights the possible role of mitochondrial metabolism in APL patients treated with ATRA.

Pereira-Martins, D.a., Coelho-Silva, J.l., Weinhäuser, I., Franca-Neto, P.l., Silveira, D.r., Ortiz, C., et al. (2022). Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia. BRITISH JOURNAL OF HAEMATOLOGY [10.1111/bjh.18510].

Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia

Ottone, Tiziana;Noguera, Nelida I;Voso, Maria T;
2022-10-20

Abstract

Although a growing body of evidence demonstrates that altered mtDNA content (mtDNAc) has clinical implications in several types of solid tumours, its prognostic relevance in acute promyelocytic leukaemia (APL) patients remains largely unknown. Here, we show that patients with higher-than-normal mtDNAc had better outcomes regardless of tumour burden. These results were more evident in patients with low-risk of relapse. The multivariate Cox proportional hazard model demonstrated that high mtDNAc was independently associated with a decreased cumulative incidence of relapse. Altogether, our data highlights the possible role of mitochondrial metabolism in APL patients treated with ATRA.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15
English
ATRA
anthracycline-based chemotherapy
mtDNA content
oxidative phosphorylation
Pereira-Martins, D.a., Coelho-Silva, J.l., Weinhäuser, I., Franca-Neto, P.l., Silveira, D.r., Ortiz, C., et al. (2022). Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia. BRITISH JOURNAL OF HAEMATOLOGY [10.1111/bjh.18510].
Pereira-Martins, Da; Coelho-Silva, Jl; Weinhäuser, I; Franca-Neto, Pl; Silveira, Dr; Ortiz, C; Moreira-Aguiar, A; Lima, Mm; Koury, Lc; de Melo, Ra; Glória, Ab; Fagundes, Em; Lino, Bk; Pagnano, K; Bittencourt, R; Nunes, E; Traina, F; Figueiredo-Pontes, L; Keating, A; Tallman, Ms; Ribeiro, Rc; Dilon, R; Ganser, A; Sanz, Ma; Berliner, N; Valk, P; Löwenberg, B; Ottone, T; Noguera, Ni; Voso, Mt; Paoloni, F; Fazi, P; Ammatuna, E; Huls, G; Schuringa, Jj; Rego, Em; Lucena-Araujo, Ar
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/307763
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