Multiple sclerosis is an autoimmune disease predominantly affecting the white matter of the CNS, causing among functional sequelae-cortico-cortical partial or total disconnection. Since functional connectivity linking cerebral regions is reliably reflected by synchronization of their neuronal firing, in this study an electrophysiological parameter measured by magnetoencephalography was used to quantify an intra-cortical connectivity (ICC) index focused on the primary somatosensory cortical areas (S1). Twenty-one patients affected by mild (Extended Disability Scale Score, median 1,5) relapsing-remitting (RR) multiple sclerosis in the remitting phase without clinically evident sensory impairment were evaluated. Three dimensional MRI was used to quantify the lesion load, discriminating black hole and non-black hole portions, normalized by individual brain volumes. When matched with a control population, multiple sclerosis patients showed a reduced ICC combined with the complete loss of the finger-dependent functional specialization in S1 cortex of the dominant hemisphere. No association was found between ICC impairment and disease duration, or prolongation of the central sensory conduction time, presence of spinal cord lesions and ongoing disease modifying therapy. The ICC index slightly correlated with the lesion load. A local index of ICC in a circumscribed brain primary area was altered in mildly disabled RR-multiple sclerosis patients, also in absence of any impairment of central sensory conduction. In conclusion, the diffuse damage influencing the multi-nodal network subtending complex cerebral functions also affects intrinsic cortical connectivity. The S1 ICC index is proposed as a highly sensitive and simple-to-test functional measure for the evaluation of intra-cortical synchronization mechanisms in RR-multiple sclerosis.

Tecchio, F., Zito, G., Zappasodi, F., Dell' Acqua, M.l., Landi, D., Nardo, D., et al. (2008). Intra-cortical connectivity in multiple sclerosis: a neurophysiological approach. BRAIN, 131(Pt 7), 1783-1792 [10.1093/brain/awn087].

Intra-cortical connectivity in multiple sclerosis: a neurophysiological approach

Landi, Doriana;Lupoi, Domenico;
2008-07-01

Abstract

Multiple sclerosis is an autoimmune disease predominantly affecting the white matter of the CNS, causing among functional sequelae-cortico-cortical partial or total disconnection. Since functional connectivity linking cerebral regions is reliably reflected by synchronization of their neuronal firing, in this study an electrophysiological parameter measured by magnetoencephalography was used to quantify an intra-cortical connectivity (ICC) index focused on the primary somatosensory cortical areas (S1). Twenty-one patients affected by mild (Extended Disability Scale Score, median 1,5) relapsing-remitting (RR) multiple sclerosis in the remitting phase without clinically evident sensory impairment were evaluated. Three dimensional MRI was used to quantify the lesion load, discriminating black hole and non-black hole portions, normalized by individual brain volumes. When matched with a control population, multiple sclerosis patients showed a reduced ICC combined with the complete loss of the finger-dependent functional specialization in S1 cortex of the dominant hemisphere. No association was found between ICC impairment and disease duration, or prolongation of the central sensory conduction time, presence of spinal cord lesions and ongoing disease modifying therapy. The ICC index slightly correlated with the lesion load. A local index of ICC in a circumscribed brain primary area was altered in mildly disabled RR-multiple sclerosis patients, also in absence of any impairment of central sensory conduction. In conclusion, the diffuse damage influencing the multi-nodal network subtending complex cerebral functions also affects intrinsic cortical connectivity. The S1 ICC index is proposed as a highly sensitive and simple-to-test functional measure for the evaluation of intra-cortical synchronization mechanisms in RR-multiple sclerosis.
lug-2008
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
magnetoencephalography
cerebral connectivity
primary sensorimotor cortex
lesion load black holes
Adult
Brain Mapping
Cerebral Cortex
Disability Evaluation
Female
Humans
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Magnetoencephalography
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting
Neural Pathways
Signal Processing, Computer-Assisted
Time Factors
Tecchio, F., Zito, G., Zappasodi, F., Dell' Acqua, M.l., Landi, D., Nardo, D., et al. (2008). Intra-cortical connectivity in multiple sclerosis: a neurophysiological approach. BRAIN, 131(Pt 7), 1783-1792 [10.1093/brain/awn087].
Tecchio, F; Zito, G; Zappasodi, F; Dell' Acqua, Ml; Landi, D; Nardo, D; Lupoi, D; Rossini, Pm; Filippi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/306412
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