Background: The approval of an increasing number of disease modifying drugs for the treatment of Multiple Sclerosis (MS) creates new challenges for patients and clinicians on the first treatment choice. The main aim of this study was to assess factors impacting first therapy choice in a large Italian MS cohort. Methods: Newly diagnosed relapsing -remitting (RR) MS patients (2010-2018) followed in 24 Italian MS centres were included in the study. We evaluated the association of baseline demographics, clinical and MRI char- acteristics to the first treatment choice by logistic regression models applied to pre -de fined binary alternatives:

Maniscalco, G.t., Saccà, F., Lanzillo, R., Annovazzi, P., Baroncini, D., Binello, E., et al. (2020). First therapy choice in newly diagnosed Multiple Sclerosis patients: A multicenter Italian study. MULTIPLE SCLEROSIS AND RELATED DISORDERS, 42, 102059 [10.1016/j.msard.2020.102059].

First therapy choice in newly diagnosed Multiple Sclerosis patients: A multicenter Italian study

Mataluni, Giorgia;Landi, Doriana;
2020-07-01

Abstract

Background: The approval of an increasing number of disease modifying drugs for the treatment of Multiple Sclerosis (MS) creates new challenges for patients and clinicians on the first treatment choice. The main aim of this study was to assess factors impacting first therapy choice in a large Italian MS cohort. Methods: Newly diagnosed relapsing -remitting (RR) MS patients (2010-2018) followed in 24 Italian MS centres were included in the study. We evaluated the association of baseline demographics, clinical and MRI char- acteristics to the first treatment choice by logistic regression models applied to pre -de fined binary alternatives:
lug-2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Determinants first therapy
Immunomodulatory therapy
Multiple sclerosis
Naive
Relapsing-remitting
Aged
Dimethyl Fumarate
Fingolimod Hydrochloride
Humans
Immunosuppressive Agents
Italy
Male
Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting
Maniscalco, G.t., Saccà, F., Lanzillo, R., Annovazzi, P., Baroncini, D., Binello, E., et al. (2020). First therapy choice in newly diagnosed Multiple Sclerosis patients: A multicenter Italian study. MULTIPLE SCLEROSIS AND RELATED DISORDERS, 42, 102059 [10.1016/j.msard.2020.102059].
Maniscalco, Gt; Saccà, F; Lanzillo, R; Annovazzi, P; Baroncini, D; Binello, E; Repice, A; Perini, P; Clerico, M; Mataluni, G; Bonavita, S; La Gioia, S; Gutierrez, Lp; Laroni, A; Frau, J; Cocco, E; Torri Clerici, V; Zarbo, Ir; Sartori, A; Signoriello, E; Rasia, S; Cordioli, C; Stromillo, Ml; Cerqua, R; Pontecorvo, S; Di Sapio, A; Grasso, R; Barone, S; Lavorgna, L; Barrilà, C; Landi, D; Russo, Cv; Frigeni, B; Ippolito, D; Turano, G; Carmisciano, L; Sormani, Mp; Signori, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/306395
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