Myeloid sarcoma is a hematologic malignancy consisting of extramedullary tissue involvement by myeloid blasts, usually considered as acute myeloid leukemia and treated accordingly. The disease itself, together with chemotherapy and disease-associated factors, may have an impact in increasing the risk of developing severe and frequently life-threatening infections. Herein, we describe the case of a patient with a right breast skin lesion, histologically diagnosed myeloid sarcoma, who developed a severe disseminated fungal infection by Saprochaete clavata (Magnusiomyces clavatus), during the first consolidation course of chemotherapy. Despite maximum antifungal therapy, the infection progressed and the fungus continued to be isolated until granulocyte transfusion therapy was initiated. Our experience suggests that patients with profound and long-lasting neutropenia could benefit from granulocyte transfusions as additional therapy in severe fungal infections resistant to broad-spectrum antimicrobial therapy.

Pasqualone, G., Buzzatti, E., Palmieri, R., Savi, A., Pascale, M.r., Borsellino, B., et al. (2022). Case report: A Saprochaete clavata (Magnusiomyces clavatus) severe infection effectively treated with granulocyte transfusion in a young patient with myeloid sarcoma. FRONTIERS IN ONCOLOGY, 12(970188), 1-7 [10.3389/fonc.2022.970188].

Case report: A Saprochaete clavata (Magnusiomyces clavatus) severe infection effectively treated with granulocyte transfusion in a young patient with myeloid sarcoma

Palmieri, Raffaele;Buccisano, Francesco;Voso, Maria Teresa;Venditti, Adriano;Del Principe, Maria Ilaria
2022-01-01

Abstract

Myeloid sarcoma is a hematologic malignancy consisting of extramedullary tissue involvement by myeloid blasts, usually considered as acute myeloid leukemia and treated accordingly. The disease itself, together with chemotherapy and disease-associated factors, may have an impact in increasing the risk of developing severe and frequently life-threatening infections. Herein, we describe the case of a patient with a right breast skin lesion, histologically diagnosed myeloid sarcoma, who developed a severe disseminated fungal infection by Saprochaete clavata (Magnusiomyces clavatus), during the first consolidation course of chemotherapy. Despite maximum antifungal therapy, the infection progressed and the fungus continued to be isolated until granulocyte transfusion therapy was initiated. Our experience suggests that patients with profound and long-lasting neutropenia could benefit from granulocyte transfusions as additional therapy in severe fungal infections resistant to broad-spectrum antimicrobial therapy.
2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
acute myeloid leukemia, invasive fungal infection, granulocyte transfusion, Saprochaeta clavata, Magnusiomyces clavatus, case report, myeloid sarcoma
https://doi.org/10.3389/fonc.2022.970188
Pasqualone, G., Buzzatti, E., Palmieri, R., Savi, A., Pascale, M.r., Borsellino, B., et al. (2022). Case report: A Saprochaete clavata (Magnusiomyces clavatus) severe infection effectively treated with granulocyte transfusion in a young patient with myeloid sarcoma. FRONTIERS IN ONCOLOGY, 12(970188), 1-7 [10.3389/fonc.2022.970188].
Pasqualone, G; Buzzatti, E; Palmieri, R; Savi, A; Pascale, Mr; Borsellino, B; Guarnera, L; Buccisano, F; Voso, Mt; Maurillo, L; Sconocchia, G; Venditt...espandi
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
fonc-12-970188.pdf

accesso aperto

Licenza: Copyright dell'editore
Dimensione 898.56 kB
Formato Adobe PDF
898.56 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/305976
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact