Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March-April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.

Licordari, R., Sticchi, A., Mancuso, F., Caracciolo, A., Muscoli, S., Iacovelli, F., et al. (2022). The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic. JOURNAL OF CLINICAL MEDICINE, 11(10), 2926 [10.3390/jcm11102926].

The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic

Muscoli S.;Iacovelli F.;Scoccia A.;Cammalleri V.;Tomai F.;Patti G.;Giannini F.;
2022

Abstract

Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March-April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/11
English
COVID-19
acute coronary syndrome (ACS)
bleeding
in-hospital outcomes
myocardial infarction (MI)
Licordari, R., Sticchi, A., Mancuso, F., Caracciolo, A., Muscoli, S., Iacovelli, F., et al. (2022). The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic. JOURNAL OF CLINICAL MEDICINE, 11(10), 2926 [10.3390/jcm11102926].
Licordari, R; Sticchi, A; Mancuso, F; Caracciolo, A; Muscoli, S; Iacovelli, F; Ruggiero, R; Scoccia, A; Cammalleri, V; Pavani, M; Loffi, M; Scordino, D; Ferro, J; Rognoni, A; Buono, A; Nava, S; Albani, S; Colaiori, I; Zilio, F; Borghesi, M; Regazzoni, V; Benenati, S; Pescetelli, F; De Marzo, V; Mannarini, A; Spione, F; Baldassarre, D; De Benedictis, M; Bonmassari, R; Danzi, Gb; Galli, M; Ielasi, A; Musumeci, G; Tomai, F; Pasceri, V; Porto, I; Patti, G; Campo, G; Colombo, A; Micari, A; Giannini, F; Costa, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/304916
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