Primary sclerosing cholangitis (PSC) is characterized by biliary senescence and hepatic fibrosis. Melatonin exerts its effects by interacting with MT1/MT2 melatonin receptors. Short-term (1 wk) melatonin treatment reduces a ductular reaction and liver fibrosis in bile duct-ligated rats by down-regulation of MT1 and clock genes, and in Mdr2-/- mice by decreased miR200b-dependent angiogenesis. We aimed to evaluate the long-term effects of melatonin on liver phenotype that may be mediated by changes in MT1/clock genes/miR200b/maspin/glutathione-S transferase (GST) signaling.

Ceci, L., Chen, L., Baiocchi, L., Wu, N., Kennedy, L., Carpino, G., et al. (2022). Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model. CMGH, 14(4), 877-904 [10.1016/j.jcmgh.2022.07.007].

Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model

Baiocchi, Leonardo;
2022-07-19

Abstract

Primary sclerosing cholangitis (PSC) is characterized by biliary senescence and hepatic fibrosis. Melatonin exerts its effects by interacting with MT1/MT2 melatonin receptors. Short-term (1 wk) melatonin treatment reduces a ductular reaction and liver fibrosis in bile duct-ligated rats by down-regulation of MT1 and clock genes, and in Mdr2-/- mice by decreased miR200b-dependent angiogenesis. We aimed to evaluate the long-term effects of melatonin on liver phenotype that may be mediated by changes in MT1/clock genes/miR200b/maspin/glutathione-S transferase (GST) signaling.
19-lug-2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/12 - GASTROENTEROLOGIA
English
Cholangiopathies
Circadian Rhythm
Ductular Reaction
TGF-β1
Ceci, L., Chen, L., Baiocchi, L., Wu, N., Kennedy, L., Carpino, G., et al. (2022). Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model. CMGH, 14(4), 877-904 [10.1016/j.jcmgh.2022.07.007].
Ceci, L; Chen, L; Baiocchi, L; Wu, N; Kennedy, L; Carpino, G; Kyritsi, K; Zhou, T; Owen, T; Kundu, D; Sybenga, A; Isidan, A; Ekser, B; Franchitto, A; ...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/304694
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