Ongoing with current combinations of antiretroviral drugs for the treatment of Human Immunodeficiency Virus (HIV) infection can successfully maintain long-term suppression of HIV-1 replication in plasma. Still, none of these therapies is capable of extinguishing the virus from the long-lived cellular reservoir, including monocyte-derived macrophages (MDM), that means the principal obstacle to HIV cure. MDM are widely distributed in all tissues and organs, including central system nervous (CNS) where they represent the most frequent HIV-infected cells that means the principal obstacle to HIV cure. Current FDA-approved antiretroviral drugs target viral reverse transcriptase, protease, integrase, and entry processes (coreceptor or fusion blockade). It is desirable to continue to develop new antiretrovirals directed against alternative targets in the virus lifecycle in order to further optimize therapeutic options, overcome resistance to existing medications, and potentially contribute to the elimination of viral reservoirs.This review provides a comprehensive overview of the activity of antiretroviral drugs (classical and upcoming) in monocytes-derived macrophages (MDM). Defining the antiviral activity of these drugs in this important cellular HIV-1 reservoir provides crucial hints about their efficacy in HIV-1 infected patients.

Aquaro, S., Borrajo, A., Pellegrino, M., Svicher, V. (2020). Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages, 11(1), 400-413 [10.1080/21505594.2020.1760443].

Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages

Aquaro, Stefano;Svicher, Valentina
2020

Abstract

Ongoing with current combinations of antiretroviral drugs for the treatment of Human Immunodeficiency Virus (HIV) infection can successfully maintain long-term suppression of HIV-1 replication in plasma. Still, none of these therapies is capable of extinguishing the virus from the long-lived cellular reservoir, including monocyte-derived macrophages (MDM), that means the principal obstacle to HIV cure. MDM are widely distributed in all tissues and organs, including central system nervous (CNS) where they represent the most frequent HIV-infected cells that means the principal obstacle to HIV cure. Current FDA-approved antiretroviral drugs target viral reverse transcriptase, protease, integrase, and entry processes (coreceptor or fusion blockade). It is desirable to continue to develop new antiretrovirals directed against alternative targets in the virus lifecycle in order to further optimize therapeutic options, overcome resistance to existing medications, and potentially contribute to the elimination of viral reservoirs.This review provides a comprehensive overview of the activity of antiretroviral drugs (classical and upcoming) in monocytes-derived macrophages (MDM). Defining the antiviral activity of these drugs in this important cellular HIV-1 reservoir provides crucial hints about their efficacy in HIV-1 infected patients.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07
English
HIV-1
antiretroviral drugs target
macrophages
virus reservoir
Animals
Anti-Retroviral Agents
Central Nervous System
Clinical Trials as Topic
Disease Reservoirs
HIV Infections
HIV-1
Humans
Macrophages
Mice
Virus Replication
Aquaro, S., Borrajo, A., Pellegrino, M., Svicher, V. (2020). Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages, 11(1), 400-413 [10.1080/21505594.2020.1760443].
Aquaro, S; Borrajo, A; Pellegrino, M; Svicher, V
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/304356
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