A new NMR method is presented to measure selectively the self-diffusion coefficient of molecules with 13C-1H bonds. The method is based on the selection of spectral lines by both 13C chemical-shift and 13C-1H J-coupling encoding, which generally is adequate to individuate a molecular species. Although the approach has preferential utilization in bio-molecular systems, it may be employed when a direct or indirect chemical bond has chemical shift and J-coupling coordinates able to localize uniquely a certain molecular species. The method may also be utilized to attain self-diffusion weighted NMR imaging (MRI) of single molecular species. Here results on glucose metabolites in aqueous solutions are presented. The approach shows a chemical selectivity, which is higher than the traditional NMR stimulated echo approach. © 2004 Elsevier B.V. All rights reserved.

Casieri, C., Testa, C., Paci, M., & De Luca, F. (2004). Molecular self-diffusion measurement by stimulated echo of selected 13C-1H bonds: Case of the glucose metabolites. CHEMICAL PHYSICS LETTERS, 387, 295-300 [10.1016/j.cplett.2004.02.024].

Molecular self-diffusion measurement by stimulated echo of selected 13C-1H bonds: Case of the glucose metabolites

PACI, MAURIZIO;
2004

Abstract

A new NMR method is presented to measure selectively the self-diffusion coefficient of molecules with 13C-1H bonds. The method is based on the selection of spectral lines by both 13C chemical-shift and 13C-1H J-coupling encoding, which generally is adequate to individuate a molecular species. Although the approach has preferential utilization in bio-molecular systems, it may be employed when a direct or indirect chemical bond has chemical shift and J-coupling coordinates able to localize uniquely a certain molecular species. The method may also be utilized to attain self-diffusion weighted NMR imaging (MRI) of single molecular species. Here results on glucose metabolites in aqueous solutions are presented. The approach shows a chemical selectivity, which is higher than the traditional NMR stimulated echo approach. © 2004 Elsevier B.V. All rights reserved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore CHIM/02 - Chimica Fisica
English
Con Impact Factor ISI
carbon 13; glucose; hydrogen; article; diffusion; diffusion coefficient; hydrogen bond; measurement; metabolite; molecular dynamics; nuclear magnetic resonance; nuclear magnetic resonance imaging; proton nuclear magnetic resonance; stimulation
Casieri, C., Testa, C., Paci, M., & De Luca, F. (2004). Molecular self-diffusion measurement by stimulated echo of selected 13C-1H bonds: Case of the glucose metabolites. CHEMICAL PHYSICS LETTERS, 387, 295-300 [10.1016/j.cplett.2004.02.024].
Casieri, C; Testa, C; Paci, M; De Luca, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/30435
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