p73, like its homologue, the tumor suppressor p53, is able to induce apoptosis in several cell types. This property is important for the involvement of p73 in cancer development and therapy. However, in contrast with p53, the TAp73 gene has two distinct promoters coding for two protein isoforms with opposite effects: while the transactivation proficient TAp73 shows pro-apoptotic effects, the amino-terminal-deleted ΔNp73 has an anti-apoptotic function. Indeed, the relative expression of these two proteins is related to the prognosis of several cancers. Here we discuss recent developments in the control of p73-induced apoptosis. First, TAp73 induces ER stress via the direct transactivation of Scotin. Second, TAp73 induces the mitochondrial pathway by directly transactivating both Bax and the BH3 only protein PUMA promoters. While the first transactivation is weak, and not sufficient to trigger apoptosis (at least in the in vitro cellular models so far evaluated), the induction of PUMA is strong and lethal. Third, the promoter of the death receptor CD95 contains a p53 responsive element and preliminary experiments suggest that TAp73 also activates the death receptor pathway. In addition, TAp73 is able to transactivate its own second promoter, thus inducing the expression of the anti-apoptotic ΔNp73 isoform. Therefore, the balance between TAp73 and ΔNp73 finely regulates cellular sensitivity to death. © 2005 Elsevier Inc. All rights reserved.

Ramadan S., T.A. (2005). p73 induces apoptosis by different mechanisms. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331(3), 713-717 [10.1016/j.bbrc.2005.03.156].

p73 induces apoptosis by different mechanisms

Terrinoni A.;CATANI, MARIA VALERIA;MELINO, GENNARO;CANDI, ELEONORA
2005

Abstract

p73, like its homologue, the tumor suppressor p53, is able to induce apoptosis in several cell types. This property is important for the involvement of p73 in cancer development and therapy. However, in contrast with p53, the TAp73 gene has two distinct promoters coding for two protein isoforms with opposite effects: while the transactivation proficient TAp73 shows pro-apoptotic effects, the amino-terminal-deleted ΔNp73 has an anti-apoptotic function. Indeed, the relative expression of these two proteins is related to the prognosis of several cancers. Here we discuss recent developments in the control of p73-induced apoptosis. First, TAp73 induces ER stress via the direct transactivation of Scotin. Second, TAp73 induces the mitochondrial pathway by directly transactivating both Bax and the BH3 only protein PUMA promoters. While the first transactivation is weak, and not sufficient to trigger apoptosis (at least in the in vitro cellular models so far evaluated), the induction of PUMA is strong and lethal. Third, the promoter of the death receptor CD95 contains a p53 responsive element and preliminary experiments suggest that TAp73 also activates the death receptor pathway. In addition, TAp73 is able to transactivate its own second promoter, thus inducing the expression of the anti-apoptotic ΔNp73 isoform. Therefore, the balance between TAp73 and ΔNp73 finely regulates cellular sensitivity to death. © 2005 Elsevier Inc. All rights reserved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/11
English
Con Impact Factor ISI
Apoptosis; Bax; Cancer; CD95; Cell death; Death receptor; DNA damage; p53; p63; p73; PUMA; Scotin
Ramadan S., T.A. (2005). p73 induces apoptosis by different mechanisms. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331(3), 713-717 [10.1016/j.bbrc.2005.03.156].
Ramadan, S; Terrinoni, A; Catani, Mv; Sayan, Ae; Knight, Ra; Mueller, M; Krammer, Ph; Melino, G; Candi, E
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/30430
Citazioni
  • ???jsp.display-item.citation.pmc??? 57
  • Scopus 126
  • ???jsp.display-item.citation.isi??? 128
social impact