Administration of active TG2 to two different in vitro angiogenesis assays resulted in the accumulation of a complex extracellular matrix (ECM) leading to the suppression of endothelial tube formation without causing cell death. Matrix accumulation was accompanied by a decreased rate of ECM turnover, with increased resistance to matrix metallo-proteinase-1. Intratumor injection of TG2 into mice bearing CT26 colon carcinoma tumors demonstrated a reduction in tumor growth, and in some cases tumor regression. In TG2 knockout mice, tumor progression was increased and survival rate reduced compared to wild-type mice. In wild-type mice, an increased presence of TG2 was detectable in the host tissue around the tumor. Analysis of CT26 tumors injected with TG2 revealed fibrotic-like tissue containing increased collagen, TG2-mediated crosslink and reduced organized vasculature. TG2-mediated modulation of cell behavior via changes in the ECM may provide a new approach to solid tumor therapy.
Jones, R.A., Kotsakis, P., Johnson, T.S., Chau, D., Ali, S., Melino, G., et al. (2006). Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth. CELL DEATH AND DIFFERENTIATION, 13(9), 1442-1453.
Tipologia: | Articolo su rivista |
Citazione: | Jones, R.A., Kotsakis, P., Johnson, T.S., Chau, D., Ali, S., Melino, G., et al. (2006). Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth. CELL DEATH AND DIFFERENTIATION, 13(9), 1442-1453. |
Altre informazioni significative: | 12 |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/11 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/sj.cdd.4401816 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2006 |
Titolo: | Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth |
Autori: | |
Autori: | Jones, RA; Kotsakis, P; Johnson, TS; Chau, DYS; Ali, S; Melino, G; Griffin, M |
Appare nelle tipologie: | 01 - Articolo su rivista |