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EnglishAdministration of active TG2 to two different in vitro angiogenesis assays resulted in the accumulation of a complex extracellular matrix (ECM) leading to the suppression of endothelial tube formation without causing cell death. Matrix accumulation was accompanied by a decreased rate of ECM turnover, with increased resistance to matrix metallo-proteinase-1. Intratumor injection of TG2 into mice bearing CT26 colon carcinoma tumors demonstrated a reduction in tumor growth, and in some cases tumor regression. In TG2 knockout mice, tumor progression was increased and survival rate reduced compared to wild-type mice. In wild-type mice, an increased presence of TG2 was detectable in the host tissue around the tumor. Analysis of CT26 tumors injected with TG2 revealed fibrotic-like tissue containing increased collagen, TG2-mediated crosslink and reduced organized vasculature. TG2-mediated modulation of cell behavior via changes in the ECM may provide a new approach to solid tumor therapy.
Jones, R.A., Kotsakis, P., Johnson, T.S., Chau, D., Ali, S., Melino, G., et al. (2006). Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth. CELL DEATH AND DIFFERENTIATION, 13(9), 1442-1453.
| Tipologia: | Articolo su rivista |
| Citazione: | Jones, R.A., Kotsakis, P., Johnson, T.S., Chau, D., Ali, S., Melino, G., et al. (2006). Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth. CELL DEATH AND DIFFERENTIATION, 13(9), 1442-1453. |
| Altre informazioni significative: | 12 |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore BIO/11 |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/sj.cdd.4401816 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 2006 |
| Titolo: | Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth |
| Autori: | |
| Autori: | Jones, RA; Kotsakis, P; Johnson, TS; Chau, DYS; Ali, S; Melino, G; Griffin, M |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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http://hdl.handle.net/2108/30427
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