TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases.

Cecconi, F., Nazio, F. (2021). TFG: a novel regulator of ULK1-dependent autophagy. MOLECULAR & CELLULAR ONCOLOGY, 8(4), 1945895 [10.1080/23723556.2021.1945895].

TFG: a novel regulator of ULK1-dependent autophagy

Cecconi, Francesco
;
2021

Abstract

TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/06
English
ERGIC
TFG
ULK1
neurological disorders
omegasome
Cecconi, F., Nazio, F. (2021). TFG: a novel regulator of ULK1-dependent autophagy. MOLECULAR & CELLULAR ONCOLOGY, 8(4), 1945895 [10.1080/23723556.2021.1945895].
Cecconi, F; Nazio, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/303783
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