Several studies have demonstrated a strong relation between periodontal diseases and chronic kidney disease (CKD). The main mechanisms at the base of this link are malnutrition, vitamin dysregulation, especially of B-group vitamins and of C and D vitamins, oxidative stress, metabolic acidosis and low-grade inflammation. In particular, in hemodialysis (HD) adult patients, an impairment of nutritional status has been observed, induced not only by the HD procedures themselves, but also due to numerous CKD-related comorbidities. The alteration of nutritional assessment induces systemic manifestations that have repercussions on oral health, like oral microbiota dysbiosis, slow healing of wounds related to hypovitaminosis C, and an alteration of the supporting bone structures of the oral cavity related to metabolic acidosis and vitamin D deficiency. Low-grade inflammation has been observed to characterize periodontal diseases locally and, in a systemic manner, CKD contributes to the amplification of the pathological process, bidirectionally. Therefore, CKD and oral disease patients should be managed by a multidisciplinary professional team that can evaluate the possible co-presence of these two pathological conditions, that negatively influence each other, and set up therapeutic strategies to treat them. Once these patients have been identified, they should be included in a follow-up program, characterized by periodic checks in order to manage these pathological conditions.

Costacurta, M., Basilicata, M., Marrone, G., Di Lauro, M., Campolattano, V., Bollero, P., et al. (2022). The Impact of Chronic Kidney Disease on Nutritional Status and Its Possible Relation with Oral Diseases. NUTRIENTS, 14(10), 2002 [10.3390/nu14102002].

The Impact of Chronic Kidney Disease on Nutritional Status and Its Possible Relation with Oral Diseases

Costacurta, Micaela;Bollero, Patrizio;Docimo, Raffaella;Di Daniele, Nicola;Noce, Annalisa
2022-05-10

Abstract

Several studies have demonstrated a strong relation between periodontal diseases and chronic kidney disease (CKD). The main mechanisms at the base of this link are malnutrition, vitamin dysregulation, especially of B-group vitamins and of C and D vitamins, oxidative stress, metabolic acidosis and low-grade inflammation. In particular, in hemodialysis (HD) adult patients, an impairment of nutritional status has been observed, induced not only by the HD procedures themselves, but also due to numerous CKD-related comorbidities. The alteration of nutritional assessment induces systemic manifestations that have repercussions on oral health, like oral microbiota dysbiosis, slow healing of wounds related to hypovitaminosis C, and an alteration of the supporting bone structures of the oral cavity related to metabolic acidosis and vitamin D deficiency. Low-grade inflammation has been observed to characterize periodontal diseases locally and, in a systemic manner, CKD contributes to the amplification of the pathological process, bidirectionally. Therefore, CKD and oral disease patients should be managed by a multidisciplinary professional team that can evaluate the possible co-presence of these two pathological conditions, that negatively influence each other, and set up therapeutic strategies to treat them. Once these patients have been identified, they should be included in a follow-up program, characterized by periodic checks in order to manage these pathological conditions.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/14
Settore MED/28
English
chronic kidney disease
high-protein diet
hypovitaminosis
low-grade inflammation
metabolic acidosis
Inflammation
Vitamins
Acidosis
Periodontal Diseases
Renal Insufficiency, Chronic
Nutritional status
Oral diseases
Periodontitis
Costacurta, M., Basilicata, M., Marrone, G., Di Lauro, M., Campolattano, V., Bollero, P., et al. (2022). The Impact of Chronic Kidney Disease on Nutritional Status and Its Possible Relation with Oral Diseases. NUTRIENTS, 14(10), 2002 [10.3390/nu14102002].
Costacurta, M; Basilicata, M; Marrone, G; Di Lauro, M; Campolattano, V; Bollero, P; Docimo, R; Di Daniele, N; Noce, A
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
The Impact of Chronic Kidney Disease on Nutritional Status and Its Possible Relation with Oral Diseases.pdf

solo utenti autorizzati

Tipologia: Versione Editoriale (PDF)
Licenza: Copyright dell'editore
Dimensione 1.75 MB
Formato Adobe PDF
1.75 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/303754
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact