Background Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe. Objectives To elucidate similarities and differences of PFAS in nine Southern European centers and identify associated characteristics and unique markers of PFAS. Methods As part of the @IT.2020 Multicenter Study, 815 patients with seasonal allergic rhinitis (SAR), aged 10-60 years, were recruited in seven countries. They completed questionnaires regarding SAR, comorbidities, family history, and PFAS, and underwent skin prick testing (SPT) and serum IgE testing. Results Of the 815 patients, 167 (20.5%) reported PFAS reactions. Most commonly, eliciting foods were kiwi (58, 34.7%), peach (43, 25.7%), and melon (26, 15.6%). Reported reactions were mostly local (216/319, 67.7%), occurring within 5 min of contact with elicitors (209/319, 65.5%). Associated characteristics included positive IgE to at least one panallergen (profilin, PR-10, or nsLTP) (p = 0.007), maternal PFAS (OR: 3.716, p = 0.026), and asthma (OR: 1.752, p = 0.073). Between centers, heterogeneity in prevalence (Marseille: 7.5% vs. Rome: 41.4%, p < 0.001) and of clinical characteristics was apparent. Cypress played a limited role, with only 1/22 SPT mono-sensitized patients reporting a food reaction (p < 0.073). Conclusions PFAS is a frequent comorbidity in Southern European SAR patients. Significant heterogeneity of clinical characteristics in PFAS patients among the centers was observed and may be related to the different pollen sensitization patterns in each geographic area. IgE to panallergen(s), maternal PFAS, and asthma could be PFAS-associated characteristics.

Lipp, T., Acar Sahin, A., Aggelidis, X., Arasi, S., Barbalace, A., Bourgoin, A., et al. (2021). Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study. ALLERGY, 76(10), 3041-3052 [10.1111/all.14742].

Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study

Arasi S.;Travaglini A.;
2021-01-01

Abstract

Background Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe. Objectives To elucidate similarities and differences of PFAS in nine Southern European centers and identify associated characteristics and unique markers of PFAS. Methods As part of the @IT.2020 Multicenter Study, 815 patients with seasonal allergic rhinitis (SAR), aged 10-60 years, were recruited in seven countries. They completed questionnaires regarding SAR, comorbidities, family history, and PFAS, and underwent skin prick testing (SPT) and serum IgE testing. Results Of the 815 patients, 167 (20.5%) reported PFAS reactions. Most commonly, eliciting foods were kiwi (58, 34.7%), peach (43, 25.7%), and melon (26, 15.6%). Reported reactions were mostly local (216/319, 67.7%), occurring within 5 min of contact with elicitors (209/319, 65.5%). Associated characteristics included positive IgE to at least one panallergen (profilin, PR-10, or nsLTP) (p = 0.007), maternal PFAS (OR: 3.716, p = 0.026), and asthma (OR: 1.752, p = 0.073). Between centers, heterogeneity in prevalence (Marseille: 7.5% vs. Rome: 41.4%, p < 0.001) and of clinical characteristics was apparent. Cypress played a limited role, with only 1/22 SPT mono-sensitized patients reporting a food reaction (p < 0.073). Conclusions PFAS is a frequent comorbidity in Southern European SAR patients. Significant heterogeneity of clinical characteristics in PFAS patients among the centers was observed and may be related to the different pollen sensitization patterns in each geographic area. IgE to panallergen(s), maternal PFAS, and asthma could be PFAS-associated characteristics.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/02 - BOTANICA SISTEMATICA
Settore MED/01 - STATISTICA MEDICA
Settore BIO/03 - BOTANICA AMBIENTALE E APPLICATA
English
Southern Europe
oral allergy syndrome
panallergen
pollen food allergy syndrome
seasonal allergic rhinitis
Allergens
Cross Reactions
Humans
Pollen
Skin Tests
Food Hypersensitivity
Rhinitis, Allergic, Seasonal
Lipp, T., Acar Sahin, A., Aggelidis, X., Arasi, S., Barbalace, A., Bourgoin, A., et al. (2021). Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study. ALLERGY, 76(10), 3041-3052 [10.1111/all.14742].
Lipp, T; Acar Sahin, A; Aggelidis, X; Arasi, S; Barbalace, A; Bourgoin, A; Bregu, B; Brighetti, Ma; Caeiro, E; Caglayan Sozmen, S; Caminiti, L; Charpin, D; Couto, M; Delgado, L; Di Rienzo Businco, A; Dimier, C; Dimou, Mv; Fonseca, Ja; Goksel, O; Guvensen, A; Hernandez, D; Hoffmann, Tm; Jang, Dt; Kalpaklioglu, F; Lame, B; Llusar, R; Makris, Mp; Mazon, A; Mesonjesi, E; Nieto, A; Ozturk, A; Pahus, L; Pajno, Gb; Panasiti, I; Papadopoulos, Ng; Pellegrini, E; Pelosi, S; Pereira, Am; Pereira, M; Pinar, M; Potapova, E; Priftanji, A; Psarros, F; Sackesen, C; Sfika, I; Suarez, J; Thibaudon, M; Travaglini, A; Tripodi, S; Verdier, V; Villella, V; Xepapadaki, P; Yazici, D; Matricardi, Pm; Dramburg, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/302497
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