Africa is the ultimate source of modern humans and as such harbors more genetic variation than any other continent. For this reason, studies of the patterns of genetic variation in African populations are crucial to understanding how genes affect phenotypic variation, including disease predisposition. In addition, the patterns of extant genetic variation in Africa are important for understanding how genetic variation affects infectious diseases that are a major problem in Africa, such as malaria, tuberculosis, schistosomiasis, and HIV/AIDS. Therefore, elucidating the role that genetic susceptibility to infectious diseases plays is critical to improving the health of people in Africa. It is also of note that recent and ongoing social and cultural changes in sub-Saharan Africa have increased the prevalence of non-communicable diseases that will also require genetic analyses to improve disease prevention and treatment. In this review we give special attention to many of the past and ongoing studies, emphasizing those in Sub-Saharan Africans that address the role of genetic variation in human disease. © Springer-Verlag 2008.

Sirugo, G., Hennig, B.J., Adeyemo, A.A., Matimba, A., Newport, M.J., Ibrahim, M.E., et al. (2008). Genetic studies of African populations: An overview on disease susceptibility and response to vaccines and therapeutics. HUMAN GENETICS, 123(6), 557-598 [10.1007/s00439-008-0511-y].

Genetic studies of African populations: An overview on disease susceptibility and response to vaccines and therapeutics

NOVELLI, GIUSEPPE;
2008

Abstract

Africa is the ultimate source of modern humans and as such harbors more genetic variation than any other continent. For this reason, studies of the patterns of genetic variation in African populations are crucial to understanding how genes affect phenotypic variation, including disease predisposition. In addition, the patterns of extant genetic variation in Africa are important for understanding how genetic variation affects infectious diseases that are a major problem in Africa, such as malaria, tuberculosis, schistosomiasis, and HIV/AIDS. Therefore, elucidating the role that genetic susceptibility to infectious diseases plays is critical to improving the health of people in Africa. It is also of note that recent and ongoing social and cultural changes in sub-Saharan Africa have increased the prevalence of non-communicable diseases that will also require genetic analyses to improve disease prevention and treatment. In this review we give special attention to many of the past and ongoing studies, emphasizing those in Sub-Saharan Africans that address the role of genetic variation in human disease. © Springer-Verlag 2008.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/03 - Genetica Medica
English
Con Impact Factor ISI
BRCA1 protein; BRCA2 protein; cytochrome P450 2D6; diphtheria pertussis tetanus vaccine; drug metabolizing enzyme; endothelial nitric oxide synthase; epithelial sodium channel; excitatory amino acid transporter 3; G protein coupled receptor kinase; gamma interferon receptor 1; glutathione transferase M1; glutathione transferase T1; Haemophilus influenzae type b vaccine; hepatitis B vaccine; HLA DR antigen; interleukin 12; interleukin 13; interleukin 4; interleukin 5; leukotriene A4 hydrolase; measles mumps rubella vaccine; Meningococcus vaccine; oral poliomyelitis vaccine; plasminogen activator inhibitor; protein MLH1; recombinant transforming growth factor beta1; STAT6 protein; transcription factor 7 like 2; tumor necrosis factor; unindexed drug; Africa; bacterial infection; breast cancer; cardiovascular disease; cellular immunity; colorectal cancer; diabetes mellitus; disease predisposition; drug metabolism; drug response; genetic susceptibility; genetic variability; Haemophilus influenzae type b; hepatitis B; HLA system; host resistance; human; Human immunodeficiency virus infection; hyperlipidemia; hypertension; immunization; immunophenotyping; infection resistance; infection risk; infection sensitivity; leishmaniasis; leprosy; malaria; measles; neoplasm; pertussis; pharmacogenetics; phenotype; poliomyelitis; population genetics; prevalence; priority journal; prostate cancer; review; risk factor; schistosomiasis; single nucleotide polymorphism; tetanus; trachoma; tuberculosis; Africa; Communicable Diseases; Genetic Predisposition to Disease; Genetic Screening; Genome, Human; Humans; Immunotherapy, Active; Metabolic Diseases; Neoplasms; Polymorphism, Single Nucleotide; Seroepidemiologic Studies
Sirugo, G., Hennig, B.J., Adeyemo, A.A., Matimba, A., Newport, M.J., Ibrahim, M.E., et al. (2008). Genetic studies of African populations: An overview on disease susceptibility and response to vaccines and therapeutics. HUMAN GENETICS, 123(6), 557-598 [10.1007/s00439-008-0511-y].
Sirugo, G; Hennig, B; Adeyemo, A; Matimba, A; Newport, M; Ibrahim, M; Ryckman, K; Tacconelli, A; Mariani Costantini, R; Novelli, G; Soodyall, H; Rotimi, C; Ramesar, R; Tishkoff, S; Williams, S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/30248
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