Introduction: It is known that warfarin treatment is problematic, due to its narrow therapeutic range and to the great interindividual variability. Numerous papers have shown the important contribution of CYP2C9 and VKORC1 genetic variants to this variability. Recently, a new SNP within the CYP4F2 gene was found associated with warfarin dose in the USA.

Borgiani, P., Ciccacci, C., Forte, V., Sirianni, E., Novelli, L., Bramanti, P., et al. (2009). CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population. PHARMACOGENOMICS, 10(2), 261-266 [10.2217/14622416.10.2.261].

CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population

BORGIANI, PAOLA;CICCACCI, CINZIA;NOVELLI, GIUSEPPE
2009-02-01

Abstract

Introduction: It is known that warfarin treatment is problematic, due to its narrow therapeutic range and to the great interindividual variability. Numerous papers have shown the important contribution of CYP2C9 and VKORC1 genetic variants to this variability. Recently, a new SNP within the CYP4F2 gene was found associated with warfarin dose in the USA.
feb-2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/03 - GENETICA MEDICA
English
Con Impact Factor ISI
Genetic Variation; Anticoagulants; Dose-Response Relationship, Drug; Humans; Aged; Warfarin; Italy; Genotype; Heart Valve Prosthesis Implantation; Cohort Studies; Cytochrome P-450 Enzyme System; Rome; DNA; Venous Thrombosis; Atrial Fibrillation; Mixed Function Oxygenases; Male; Female
Borgiani, P., Ciccacci, C., Forte, V., Sirianni, E., Novelli, L., Bramanti, P., et al. (2009). CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population. PHARMACOGENOMICS, 10(2), 261-266 [10.2217/14622416.10.2.261].
Borgiani, P; Ciccacci, C; Forte, V; Sirianni, E; Novelli, L; Bramanti, P; Novelli, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/29948
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