One of the pathways leading to cervical cancer is a loss of normal cell cycle control. Topoisomerase IIalpha and IIbeta are important nuclear proteins controlling the G2/M checkpoint, and shown to be over-expressed in many human cancers. Their links to oncogenic human papillomavirus (HPV) types and their prognostic value in cervical cancer are practically unexplored.

Branca, M., Giorgi, C., Ciotti, M., Santini, D., Di Bonito, L., Costa, S., et al. (2006). Over-expression of topoisomerase IIalpha is related to the grade of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HPV), but does not predict prognosis in cervical cancer or HPV clearance after cone treatment. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 25(4), 383-392 [10.1097/01.pgp.0000209573.54457.32].

Over-expression of topoisomerase IIalpha is related to the grade of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HPV), but does not predict prognosis in cervical cancer or HPV clearance after cone treatment

COSTA, STEFANO;FAVALLI, CARTESIO;
2006-10-01

Abstract

One of the pathways leading to cervical cancer is a loss of normal cell cycle control. Topoisomerase IIalpha and IIbeta are important nuclear proteins controlling the G2/M checkpoint, and shown to be over-expressed in many human cancers. Their links to oncogenic human papillomavirus (HPV) types and their prognostic value in cervical cancer are practically unexplored.
ott-2006
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
DNA Topoisomerases, Type II; DNA-Binding Proteins; Humans; Gene Expression; Prognosis; Antigens, Neoplasm; Papillomaviridae; Cervical Intraepithelial Neoplasia; Uterine Cervical Neoplasms; DNA, Viral; Polymerase Chain Reaction; Papillomavirus Infections; Immunohistochemistry; Female
Branca, M., Giorgi, C., Ciotti, M., Santini, D., Di Bonito, L., Costa, S., et al. (2006). Over-expression of topoisomerase IIalpha is related to the grade of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HPV), but does not predict prognosis in cervical cancer or HPV clearance after cone treatment. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 25(4), 383-392 [10.1097/01.pgp.0000209573.54457.32].
Branca, M; Giorgi, C; Ciotti, M; Santini, D; Di Bonito, L; Costa, S; Benedetto, A; Bonifacio, D; Di Bonito, P; Paba, P; Accardi, L; Mariani, L; Ruutu, M; Syrjänen, S; Favalli, C; Syrjänen, K
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/29808
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 23
social impact