: Ovarian age is classically considered the main cause of female reproductive infertility. In women, the process proceeds as an ongoing decline in the primordial follicle stockpile and it is associated with reduced fertility in the mid-thirties, irregular menstruation from the mid-forties, cessation of fertility, and, eventually, menopause in the early fifties. Reproductive aging is historically associated with changes in oocyte quantity and quality. However, besides the oocyte, other cellular as well as environmental factors have been the focus of more recent investigations suggesting that ovarian decay is a complex and multifaceted process. Among these factors, we will consider mitochondria and oxidative stress as related to nutrition, changes in extracellular matrix molecules, and the associated ovarian stromal compartment where immune cells of both the native and adaptive systems seem to play an important role. Understanding such processes is crucial to design treatment strategies to  slow down ovarian aging and consequently prolong reproductive lifespan and, more to this, alleviaingt side effects of menopause on the musculoskeletal, cardiovascular, and nervous systems.

Camaioni, A., Ucci, M.a., Campagnolo, L., De Felici, M., Klinger, F.g. (2022). The process of ovarian aging: it is not just about oocytes and granulosa cells. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS [10.1007/s10815-022-02478-0].

The process of ovarian aging: it is not just about oocytes and granulosa cells

Camaioni A.;Campagnolo L.;De Felici M.;Klinger F. G.
2022-03-29

Abstract

: Ovarian age is classically considered the main cause of female reproductive infertility. In women, the process proceeds as an ongoing decline in the primordial follicle stockpile and it is associated with reduced fertility in the mid-thirties, irregular menstruation from the mid-forties, cessation of fertility, and, eventually, menopause in the early fifties. Reproductive aging is historically associated with changes in oocyte quantity and quality. However, besides the oocyte, other cellular as well as environmental factors have been the focus of more recent investigations suggesting that ovarian decay is a complex and multifaceted process. Among these factors, we will consider mitochondria and oxidative stress as related to nutrition, changes in extracellular matrix molecules, and the associated ovarian stromal compartment where immune cells of both the native and adaptive systems seem to play an important role. Understanding such processes is crucial to design treatment strategies to  slow down ovarian aging and consequently prolong reproductive lifespan and, more to this, alleviaingt side effects of menopause on the musculoskeletal, cardiovascular, and nervous systems.
29-mar-2022
Online ahead of print
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/17 - ISTOLOGIA
English
Con Impact Factor ISI
Aging
Extracellular matrix
Follicular dynamic
Immune cells
Inflammation
Macrophages
Matrisome
Mitochondria
Ovary
Oxidative stress
Camaioni, A., Ucci, M.a., Campagnolo, L., De Felici, M., Klinger, F.g. (2022). The process of ovarian aging: it is not just about oocytes and granulosa cells. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS [10.1007/s10815-022-02478-0].
Camaioni, A; Ucci, Ma; Campagnolo, L; De Felici, M; Klinger, Fg
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/297707
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