Statin interference has been suggested among the mechanisms of reduction of the antiplatelet effect of clopidogrel. We thus sought to assess the influence of rosuvastatin on clopidogrel antiplatelet action in high-risk (HR) cardiovascular patients. To set the level of platelet inhibition by combined antithrombotic treatments we retrospectively studied two populations of HR patients, one under aspirin alone, the other under aspirin plus rosuvastatin, before and after addition of clopidogrel. The effects of rosuvastatin compared with atorvastatin were then prospectively investigated in patients who underwent percutaneous coronary intervention (PCI), under clopidogrel and aspirin treatment. Light transmission platelet aggregation (LTA) was studied in response to adenosine diphosphate (ADP) (5 lM) or arachidonic acid (0.5 mM). The inhibitory effect of clopidogrel in reducing ADPinduced LTA was similar in the two HR groups of patients. No difference in ADP-induced platelet aggregation was observed in the two PCI groups of patients with either atorvastatin or rosuvastatin. In conclusion, rosuvastatin does not interfere with the antiplatelet effect of clopidogrel in patients with cardiovascular disease.

Riondino, S., Petrini, N., Donato, L., Torromeo, C., Tanzilli, G., Pulcinelli, F.m., et al. (2009). Effects of rosuvastatin on platelet inhibition by clopidogrel in cardiovascular patients. JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 28(2):, 151-155 [10.1007/s11239-008-0254-6].

Effects of rosuvastatin on platelet inhibition by clopidogrel in cardiovascular patients

RIONDINO, Silvia;BARILLA', Francesco
2009-01-01

Abstract

Statin interference has been suggested among the mechanisms of reduction of the antiplatelet effect of clopidogrel. We thus sought to assess the influence of rosuvastatin on clopidogrel antiplatelet action in high-risk (HR) cardiovascular patients. To set the level of platelet inhibition by combined antithrombotic treatments we retrospectively studied two populations of HR patients, one under aspirin alone, the other under aspirin plus rosuvastatin, before and after addition of clopidogrel. The effects of rosuvastatin compared with atorvastatin were then prospectively investigated in patients who underwent percutaneous coronary intervention (PCI), under clopidogrel and aspirin treatment. Light transmission platelet aggregation (LTA) was studied in response to adenosine diphosphate (ADP) (5 lM) or arachidonic acid (0.5 mM). The inhibitory effect of clopidogrel in reducing ADPinduced LTA was similar in the two HR groups of patients. No difference in ADP-induced platelet aggregation was observed in the two PCI groups of patients with either atorvastatin or rosuvastatin. In conclusion, rosuvastatin does not interfere with the antiplatelet effect of clopidogrel in patients with cardiovascular disease.
2009
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/04 - PATOLOGIA GENERALE
Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE
English
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000268275700006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a
Riondino, S., Petrini, N., Donato, L., Torromeo, C., Tanzilli, G., Pulcinelli, F.m., et al. (2009). Effects of rosuvastatin on platelet inhibition by clopidogrel in cardiovascular patients. JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 28(2):, 151-155 [10.1007/s11239-008-0254-6].
Riondino, S; Petrini, N; Donato, L; Torromeo, C; Tanzilli, G; Pulcinelli, Fm; Barilla', F
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
JThrombThromblys2009.pdf

solo utenti autorizzati

Dimensione 208.87 kB
Formato Adobe PDF
208.87 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/296651
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 16
social impact