Oxidative stress has been suggested as a contributor of Alzheimer disease (AD) neurodegeneration, particularly in those patients with late-onset AD (LOAD). Therefore, the authors studied the effect of glutathione S-transferase (GST) P1-M1-T1 gene polymorphisms and their interactions with the apolipoprotein E (ApoE) epsilon4 allelic variant on the three-year longitudinal course of AD.

Spalletta, G., Bernardini, S., Bellincampi, L., Federici, G., Trequattrini, A., Ciappi, F., et al. (2007). Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 15(10), 879-887 [10.1097/JGP.0b013e3180547076].

Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease

BERNARDINI, SERGIO;FEDERICI, GIORGIO;CALTAGIRONE, CARLO;
2007-10-01

Abstract

Oxidative stress has been suggested as a contributor of Alzheimer disease (AD) neurodegeneration, particularly in those patients with late-onset AD (LOAD). Therefore, the authors studied the effect of glutathione S-transferase (GST) P1-M1-T1 gene polymorphisms and their interactions with the apolipoprotein E (ApoE) epsilon4 allelic variant on the three-year longitudinal course of AD.
ott-2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Regression Analysis; Genetic Variation; Age of Onset; Polymorphism, Genetic; Humans; Alzheimer Disease; Disease Progression; Glutathione Transferase; Activities of Daily Living; Aged; Longitudinal Studies; Cognition Disorders; Genotype; Glutathione S-Transferase pi; Psychiatric Status Rating Scales; Apolipoprotein E4; Heterozygote; Oxidative Stress; Neuropsychological Tests; Male; Female
Spalletta, G., Bernardini, S., Bellincampi, L., Federici, G., Trequattrini, A., Ciappi, F., et al. (2007). Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 15(10), 879-887 [10.1097/JGP.0b013e3180547076].
Spalletta, G; Bernardini, S; Bellincampi, L; Federici, G; Trequattrini, A; Ciappi, F; Bria, P; Caltagirone, C; Bossù, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/29555
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